{"id":"W2105240629","doi":"10.1371/journal.ppat.1000917","title":"Perforin Expression Directly Ex Vivo by HIV-Specific CD8+ T-Cells Is a Correlate of HIV Elite Control","year":2010,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":363,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; University of Alabama at Birmingham; Howard Hughes Medical Institute","keywords":"Perforin; Biology; TIGIT; Cytotoxic T cell; Ex vivo; CD8; Degranulation; Immunology; T cell; Immune system; Cell biology; In vivo; Receptor; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002442144,0.0002449903,0.0002445427,0.000397591,0.0002031047,0.0005636743,0.0001480035,0.0001976671,0.001214551],"category_scores_gemma":[0.0005955035,0.0001066539,0.00007697217,0.0002452623,0.0002488552,0.0003791237,0.0003414288,0.0004323157,0.0001509027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001108913,"about_ca_system_score_gemma":0.00006181686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001718627,"about_ca_topic_score_gemma":0.0001347004,"domain_scores_codex":[0.9998032,0.00002824959,0.00002200184,0.00006116403,0.0000354891,0.0000498407],"domain_scores_gemma":[0.9995746,0.00009310841,0.0001432316,0.00005461693,0.00005042937,0.00008399482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007674892,0.0001613904,0.146442,0.00007619087,0.00003203104,0.0005122988,0.0003847358,0.0001317415,0.8369632,0.0001142747,0.00006372442,0.01435088],"study_design_scores_gemma":[0.00004664639,0.002437501,0.7984052,0.00002427092,0.00009523433,0.004554888,0.0004920682,0.000805029,0.1914014,0.0003684893,0.001354757,0.00001462568],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991187,0.0002561769,0.000260771,0.000007936909,0.000001703912,0.000007976381,0.00005068876,0.00000871605,0.000287333],"genre_scores_gemma":[0.9994073,0.0001239887,0.0001364588,0.00001225842,0.000007866546,0.00001024802,0.0001077612,0.000003061675,0.0001910944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001214551,"threshold_uncertainty_score":0.004063129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00953452734200619,"score_gpt":0.2175997513916768,"score_spread":0.2080652240496706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}