{"id":"W2105246337","doi":"10.4049/jimmunol.165.7.3966","title":"Granzyme Activity in the Inflamed Lung Is Not Controlled by Endogenous Serine Proteinase Inhibitors","year":2000,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"","keywords":"Serine; Endogeny; Serine Proteinase Inhibitors; Granzyme; Proteinase 3; Granzyme A; Chemistry; Granzyme B; Biochemistry; Pharmacology; Serine protease; Enzyme; Immunology; Biology; Inflammation; Cytotoxic T cell; Perforin; Protease; Myeloperoxidase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003169605,0.0001740985,0.0003368859,0.0002493162,0.0001288248,0.0005535028,0.0001114721,0.0001865339,0.000618398],"category_scores_gemma":[0.001290309,0.0001348347,0.0001367477,0.0001816836,0.0003428292,0.0002539982,0.0001991554,0.0003590834,0.0002069891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002051835,"about_ca_system_score_gemma":0.0001244279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001568742,"about_ca_topic_score_gemma":0.0001395154,"domain_scores_codex":[0.9996812,0.0001015338,0.00004061488,0.00007127059,0.00005880662,0.00004659677],"domain_scores_gemma":[0.9995309,0.0001258845,0.0001765557,0.00005573273,0.00003304569,0.00007788689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004766274,0.0001249417,0.0838089,0.0001360348,0.00009611087,0.001459783,0.0001882711,0.0002467497,0.8947882,0.0002458829,0.0001118226,0.01402699],"study_design_scores_gemma":[0.0007636436,0.005554854,0.5688928,0.00005103798,0.0003024303,0.02558465,0.0002920988,0.002500841,0.3906007,0.0009429362,0.004486676,0.0000274088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979525,0.001597913,0.000212725,0.00002600594,0.000003948879,0.000001960124,0.00002158589,0.00000782386,0.0001754477],"genre_scores_gemma":[0.9993991,0.0002901937,0.0001412617,0.00001095852,0.000009391649,0.000002412048,0.00004724745,0.000002051662,0.00009751164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000618398,"threshold_uncertainty_score":0.002068758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01848859508815009,"score_gpt":0.2542232406436349,"score_spread":0.2357346455554848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}