{"id":"W2105268691","doi":"10.2337/diabetes.53.11.2893","title":"Hepatic Lipase mRNA, Protein, and Plasma Enzyme Activity Is Increased in the Insulin-Resistant, Fructose-Fed Syrian Golden Hamster and Is Partially Normalized by the Insulin Sensitizer Rosiglitazone","year":2004,"lang":"en","type":"article","venue":"Diabetes","topic":"Diet, Metabolism, and Disease","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Heart and Stroke Foundation of Canada","keywords":"Internal medicine; Endocrinology; Rosiglitazone; Insulin; Hyperinsulinemia; Hamster; Mesocricetus; Chemistry; Hepatic lipase; Hepatocyte; Insulin resistance; Lipoprotein lipase; Biology; Medicine; Adipose tissue; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001415058,0.0003375919,0.000452259,0.0006366091,0.0001535346,0.000334249,0.000113689,0.0002338822,0.001075607],"category_scores_gemma":[0.0001628,0.0002812328,0.0003675002,0.0002164532,0.0003647495,0.0001763099,0.0002045892,0.0004463735,0.0002287303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003576695,"about_ca_system_score_gemma":0.000158223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001079351,"about_ca_topic_score_gemma":0.001557372,"domain_scores_codex":[0.9998627,0.0000144604,0.00001876168,0.00004434122,0.0000279736,0.00003182007],"domain_scores_gemma":[0.9997618,0.00001441252,0.00008348734,0.00003813364,0.00002048845,0.00008168723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009889607,0.00003833262,0.00352641,0.00002328257,0.00002228631,0.0001031708,0.0000274702,0.00002272036,0.9938681,0.00003303656,0.00003223538,0.001314138],"study_design_scores_gemma":[0.0002084831,0.003433578,0.385964,0.00001691368,0.00018931,0.001347987,0.0002317811,0.0006348162,0.6057729,0.0001149549,0.00205735,0.00002787542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988342,0.0004926766,0.0001753072,0.0000316299,0.000008395554,0.000005594021,0.0001208665,0.00002471217,0.0003066326],"genre_scores_gemma":[0.995954,0.0006805989,0.0005717725,0.00006906183,0.00001982513,0.0000337115,0.0006510322,0.00002413042,0.001995901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001079351,"threshold_uncertainty_score":0.003598213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009621298776392633,"score_gpt":0.2286755140714013,"score_spread":0.2190542152950086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}