{"id":"W2105311242","doi":"10.1038/ajg.2010.392","title":"The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD With the European Crohn's and Colitis Organization: When to Start, When to Stop, Which Drug to Choose, and How to Predict Response?","year":2010,"lang":"en","type":"review","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":408,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Calgary","funders":"","keywords":"Medicine; Infliximab; Adalimumab; Certolizumab pegol; Natalizumab; Vedolizumab; Crohn's disease; Ulcerative colitis; Inflammatory bowel disease; Azathioprine; Internal medicine; Salvage therapy; Surgery; Disease; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002021446,0.0003577464,0.0008602469,0.0001440947,0.0001926745,0.0000533813,0.0009675706,0.00004925739,0.00000573146],"category_scores_gemma":[0.0002669568,0.0001595471,0.0001415133,0.000171826,0.0007193927,0.000007198991,0.0003856903,0.0003231076,6.324116e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004204983,"about_ca_system_score_gemma":0.0001394749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006483749,"about_ca_topic_score_gemma":0.0006293693,"domain_scores_codex":[0.995038,0.003332932,0.0006042729,0.0003642484,0.0002287158,0.0004318246],"domain_scores_gemma":[0.9971093,0.0002099074,0.001175774,0.0006488364,0.0006031442,0.0002530548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.6786915,0.0007576838,0.04524579,0.0006103542,0.00431194,0.0001600562,0.004246861,0.0004581258,0.008221588,0.0001088191,0.1061126,0.1510746],"study_design_scores_gemma":[0.00326677,0.06053112,0.3518751,0.001245348,0.0004941877,0.000671775,0.0009497714,0.00000140054,0.0004235043,0.00002073458,0.5801677,0.0003526201],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9687876,0.004546822,0.0006930702,0.02355703,0.0001745915,0.001954288,0.0002788304,0.00000377632,0.000004046537],"genre_scores_gemma":[0.8875306,0.0968114,0.001357551,0.01282915,0.0006752328,0.0002540945,0.00005414465,0.0001739471,0.0003139256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6754248,"threshold_uncertainty_score":0.6506142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008939736599203016,"score_gpt":0.2508371440574226,"score_spread":0.2418974074582196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}