{"id":"W2105311242","doi":"10.1038/ajg.2010.392","title":"The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD With the European Crohn's and Colitis Organization: When to Start, When to Stop, Which Drug to Choose, and How to Predict Response?","year":2010,"lang":"en","type":"review","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":408,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Calgary","funders":"","keywords":"Medicine; Infliximab; Adalimumab; Certolizumab pegol; Natalizumab; Vedolizumab; Crohn's disease; Ulcerative colitis; Inflammatory bowel disease; Azathioprine; Internal medicine; Salvage therapy; Surgery; Disease; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01320531,0.002009629,0.002823304,0.001625817,0.002433678,0.009564904,0.003029142,0.02855667,0.01319087],"category_scores_gemma":[0.02793061,0.00118471,0.001954193,0.002011403,0.004973623,0.006291368,0.005189373,0.02933256,0.01519435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007537044,"about_ca_system_score_gemma":0.02366443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01313382,"about_ca_topic_score_gemma":0.02562228,"domain_scores_codex":[0.985277,0.003932481,0.00203952,0.001492992,0.005382472,0.001875616],"domain_scores_gemma":[0.9689953,0.008003415,0.003803589,0.001004805,0.00759434,0.01059856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007483772,0.00002025642,0.0002126734,0.0001902095,0.00001898893,0.00009571041,0.00005916646,0.00003911839,0.0001242364,0.00153425,0.9804361,0.01719428],"study_design_scores_gemma":[0.00009314988,0.00004167709,0.0006094295,0.001145285,0.00002614523,0.0001631263,0.000135162,0.00007574425,0.0001506494,0.001216632,0.9962998,0.00004320407],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.0002981682,0.03375433,0.0004476936,0.8391115,0.116097,0.000127546,0.0004758777,0.00004571847,0.009642053],"genre_scores_gemma":[0.007463359,0.0548902,0.0035912,0.7460421,0.1162942,0.000415221,0.001492234,0.00036707,0.06944459],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.02855667,"threshold_uncertainty_score":0.06983715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008939736599203016,"score_gpt":0.2508371440574226,"score_spread":0.2418974074582196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}