{"id":"W2105330325","doi":"10.1172/jci16100","title":"The α1A/C- and α1B-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse","year":2003,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":185,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of California, San Francisco; National Heart, Lung, and Blood Institute; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Heart and Stroke Foundation of Canada; American Heart Association; National Institutes of Health; National Science Foundation","keywords":"Internal medicine; Endocrinology; Muscle hypertrophy; Myocyte; Heart rate; Pressure overload; Cardiac function curve; Receptor; Knockout mouse; Stimulation; Biology; Cardiac myocyte; Genetically modified mouse; Blood pressure; Medicine; Heart failure; Cardiac hypertrophy; Transgene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002766608,0.0001080022,0.0002646356,0.00002049133,0.0001386431,0.0000525189,0.0001755653,0.0001946721,0.000004084729],"category_scores_gemma":[0.001435787,0.00005599138,0.0002257935,0.00007014343,0.0001692543,0.00001027369,0.000019721,0.0002181735,6.501517e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007531282,"about_ca_system_score_gemma":0.00007700299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002267065,"about_ca_topic_score_gemma":0.000003353021,"domain_scores_codex":[0.9982774,0.0005020731,0.0007366473,0.000169162,0.0001611777,0.000153567],"domain_scores_gemma":[0.9987945,0.000279464,0.0005244241,0.000157474,0.0001535213,0.0000906078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009962963,0.0001387087,0.008703489,0.00002338643,0.0001576366,0.000003421419,0.0001736435,0.0007125016,0.96628,0.008461929,0.009457502,0.004891438],"study_design_scores_gemma":[0.008168214,0.005408153,0.01853838,0.0001540192,0.0002155219,0.00005395813,0.002294604,0.0005114203,0.7559642,0.03602549,0.1719672,0.0006988252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969831,0.001060773,0.0003458128,0.0007825888,0.0006006778,0.0001808457,0.000002048327,0.000001964505,0.00004226746],"genre_scores_gemma":[0.9958785,0.001182359,0.001482601,0.0006161822,0.0006750234,0.00001481824,0.000008643733,0.00001076874,0.0001310944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2103159,"threshold_uncertainty_score":0.2283262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08104296557997151,"score_gpt":0.3382082378545646,"score_spread":0.2571652722745931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}