{"id":"W2105344440","doi":"10.4049/jimmunol.1100367","title":"The Liver Kinase B1 Is a Central Regulator of T Cell Development, Activation, and Metabolism","year":2011,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":230,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"AMPK; Cell biology; T cell; Cell growth; Biology; Signal transduction; Kinase; Protein kinase A; AMP-activated protein kinase; mTORC1; PI3K/AKT/mTOR pathway; Biochemistry; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001103086,0.0007070774,0.0004378686,0.000388267,0.0004805276,0.0007608345,0.0002210211,0.0003660997,0.002908099],"category_scores_gemma":[0.0001394414,0.0002002803,0.0001869203,0.000358329,0.0002851289,0.0002677242,0.0004156074,0.0005243144,0.001974848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005957539,"about_ca_system_score_gemma":0.0004342741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009305962,"about_ca_topic_score_gemma":0.0007344647,"domain_scores_codex":[0.9998615,0.00002106198,0.000009794133,0.00004291983,0.00003394808,0.00003078396],"domain_scores_gemma":[0.9998611,0.000009911658,0.00005616981,0.000006545112,0.00002632267,0.00003987251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006460031,0.00004450047,0.0024483,0.0006524533,0.00004228278,0.0004451204,0.00005602184,0.0004371721,0.9524023,0.001103641,0.002757995,0.03896416],"study_design_scores_gemma":[0.0001674614,0.001335265,0.06580152,0.0002548873,0.0001931865,0.004777097,0.0003165111,0.002237979,0.7119908,0.002383897,0.2104616,0.00007980596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6008084,0.3335844,0.02099659,0.002414202,0.0008350909,0.0001696976,0.003767972,0.001443891,0.03597965],"genre_scores_gemma":[0.9274336,0.04917997,0.004210767,0.0003335162,0.0002386126,0.0001093311,0.002132332,0.000107782,0.01625412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002908099,"threshold_uncertainty_score":0.009728611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01131133588195075,"score_gpt":0.2010691715589888,"score_spread":0.189757835677038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}