{"id":"W2105344440","doi":"10.4049/jimmunol.1100367","title":"The Liver Kinase B1 Is a Central Regulator of T Cell Development, Activation, and Metabolism","year":2011,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":230,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"AMPK; Cell biology; T cell; Cell growth; Biology; Signal transduction; Kinase; Protein kinase A; AMP-activated protein kinase; mTORC1; PI3K/AKT/mTOR pathway; Biochemistry; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003626814,0.0000897777,0.0001531117,0.00002758042,0.0001009065,0.000005496189,0.0002657982,0.0000774968,0.00004313433],"category_scores_gemma":[0.00004238166,0.00004969422,0.00005403785,0.00004473941,0.0002102845,0.00000674991,0.00007583226,0.0001128763,0.000001282582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006313488,"about_ca_system_score_gemma":0.0001300542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001503579,"about_ca_topic_score_gemma":0.000004985793,"domain_scores_codex":[0.9992611,0.0001318832,0.00028318,0.00006862471,0.00007543113,0.0001797878],"domain_scores_gemma":[0.999217,0.00002380198,0.0003589535,0.0002007968,0.0001673426,0.00003205131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006793276,0.00008153085,0.0002966819,0.00001300957,0.0004501046,0.000001023594,0.003571368,8.598621e-7,0.9034821,0.0003358661,0.002079773,0.08900837],"study_design_scores_gemma":[0.0004518751,0.00007180673,0.01946503,0.000006114668,0.00004798375,0.00001918171,0.0002653605,6.522189e-7,0.8004472,0.0001442278,0.1790289,0.00005164369],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.792296,0.2071501,0.0001585762,0.00003490115,0.0001843177,0.00004501873,0.000001812053,8.4346e-7,0.0001283958],"genre_scores_gemma":[0.932566,0.06653164,0.0003865771,0.0002085675,0.000112636,0.000001628715,0.000001145767,0.000009210809,0.0001826302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1769491,"threshold_uncertainty_score":0.2026471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01131133588195075,"score_gpt":0.2010691715589888,"score_spread":0.189757835677038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}