{"id":"W2105380856","doi":"10.1038/embor.2013.132","title":"Cyclic‐di‐GMP and cyclic‐di‐AMP activate the NLRP3 inflammasome","year":2013,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases; University of Toronto","keywords":"Inflammasome; Secretion; Second messenger system; Cell biology; Intracellular; Chemistry; Biology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004507392,0.0005560942,0.000297668,0.0004552623,0.0002851711,0.0008988652,0.0002813683,0.0012614,0.006115227],"category_scores_gemma":[0.0008024915,0.0002708513,0.0004799645,0.0003819688,0.0005660739,0.001109424,0.001052216,0.001686405,0.002383226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000732466,"about_ca_system_score_gemma":0.0006986614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004423952,"about_ca_topic_score_gemma":0.0004408082,"domain_scores_codex":[0.9996011,0.0000708142,0.00003625766,0.00004798155,0.0001223117,0.0001217204],"domain_scores_gemma":[0.9996712,0.00005399984,0.00008297853,0.00004356449,0.0000414229,0.0001068114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00336274,0.0001547367,0.0006901436,0.0003804319,0.00005615711,0.001075384,0.00008237323,0.0006309478,0.9668249,0.005517827,0.002828007,0.01839634],"study_design_scores_gemma":[0.001131396,0.0008876675,0.01262985,0.0001441981,0.00006083889,0.002909054,0.0002483831,0.002886007,0.9204615,0.01886673,0.03969133,0.00008306116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8258209,0.071438,0.03119377,0.01550109,0.003730418,0.0004360389,0.004353413,0.0009074685,0.04661898],"genre_scores_gemma":[0.9690248,0.01118758,0.00657805,0.002114526,0.0003680917,0.0002163066,0.0009595425,0.00008586506,0.009465312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006115227,"threshold_uncertainty_score":0.02045745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00563782894657165,"score_gpt":0.218542347403083,"score_spread":0.2129045184565114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}