{"id":"W2105391668","doi":"10.1091/mbc.e06-06-0478","title":"Initiation of Protein Synthesis by Hepatitis C Virus Is Refractory to Reduced eIF2 · GTP · Met-tRNA<sub>i</sub><sup>Met</sup>Ternary Complex Availability","year":2006,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Hepatitis C virus research","field":"Medicine","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health","keywords":"Biology; eIF2; Internal ribosome entry site; Eukaryotic translation; Ternary complex; Transcription preinitiation complex; Translation (biology); Initiation factor; Protein biosynthesis; Eukaryotic initiation factor; GTP'; Cell biology; Virology; Molecular biology; Messenger RNA; Biochemistry; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002126761,0.0002629042,0.0004718191,0.0002169913,0.0002385645,0.0005348116,0.000146874,0.0002586515,0.0006747976],"category_scores_gemma":[0.0003894379,0.0001764333,0.0001583326,0.0001583852,0.0002751781,0.0001761385,0.0001486868,0.0004096698,0.0003969356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004785166,"about_ca_system_score_gemma":0.0003340887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007044872,"about_ca_topic_score_gemma":0.001364875,"domain_scores_codex":[0.9997749,0.00004508658,0.00002429591,0.00003027522,0.00008353749,0.00004186368],"domain_scores_gemma":[0.9997891,0.00005515917,0.00006964809,0.00002564621,0.00003004646,0.00003052576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001041089,0.00002203092,0.000214389,0.00003030362,0.000004051714,0.00002532491,0.000006970742,0.00009639696,0.997731,0.0001152846,0.00003419807,0.00161598],"study_design_scores_gemma":[0.00001235556,0.0003051874,0.002595586,0.000006157667,0.000008646823,0.0002173045,0.000006873247,0.0008458397,0.9944279,0.00004351328,0.001526587,0.000004104884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910143,0.004369173,0.002083091,0.00008810867,0.00002554718,0.0000249605,0.0001360685,0.00009150596,0.002167357],"genre_scores_gemma":[0.9959836,0.001117923,0.001630838,0.0000336893,0.00001589977,0.00002130821,0.0002832726,0.00001708553,0.0008964072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007044872,"threshold_uncertainty_score":0.003471911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01871742060037613,"score_gpt":0.2805848705110136,"score_spread":0.2618674499106375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}