{"id":"W2105391668","doi":"10.1091/mbc.e06-06-0478","title":"Initiation of Protein Synthesis by Hepatitis C Virus Is Refractory to Reduced eIF2 · GTP · Met-tRNA<sub>i</sub><sup>Met</sup>Ternary Complex Availability","year":2006,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Hepatitis C virus research","field":"Medicine","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health","keywords":"Biology; eIF2; Internal ribosome entry site; Eukaryotic translation; Ternary complex; Transcription preinitiation complex; Translation (biology); Initiation factor; Protein biosynthesis; Eukaryotic initiation factor; GTP'; Cell biology; Virology; Molecular biology; Messenger RNA; Biochemistry; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006960472,0.0002880143,0.0006837605,0.0002265068,0.00008790695,0.000009012282,0.000496626,0.0003277388,0.0003326871],"category_scores_gemma":[0.0007730311,0.0002400158,0.0002944262,0.0004248053,0.0004767012,0.00004913923,0.0002820895,0.0003550037,0.0001072462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001978898,"about_ca_system_score_gemma":0.0001871927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004247274,"about_ca_topic_score_gemma":0.00009713631,"domain_scores_codex":[0.9966741,0.001007935,0.0007885794,0.0005717635,0.0004910276,0.0004666607],"domain_scores_gemma":[0.9978739,0.000196748,0.000343974,0.00109821,0.0003350401,0.0001521415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002024947,0.0004707717,0.02025451,0.0001949757,0.00009320642,0.00001717952,0.0001134611,0.00001415074,0.9710038,0.00002285737,0.003106406,0.004506134],"study_design_scores_gemma":[0.0005703606,0.0006983636,0.0126451,0.0001153356,0.00008644608,0.000004603523,0.00001451952,0.0001768153,0.9821307,0.0003034061,0.003057663,0.0001967028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936119,0.0004761064,0.0005456237,0.0008701185,0.00004912608,0.001421905,0.0004933025,0.00003600018,0.00249596],"genre_scores_gemma":[0.9970239,0.0001022737,0.001817246,0.0005331718,0.00004815108,0.0001429579,0.0001103396,0.0000519885,0.0001699502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01112683,"threshold_uncertainty_score":0.9787561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01871742060037613,"score_gpt":0.2805848705110136,"score_spread":0.2618674499106375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}