{"id":"W2105398998","doi":"10.1158/1078-0432.ccr-08-2635","title":"Imaging Biomarkers Predict Response to Anti-HER2 (ErbB2) Therapy in Preclinical Models of Breast Cancer","year":2009,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Biomedical Imaging and Bioengineering; National Cancer Institute","keywords":"Trastuzumab; Medicine; Apoptosis; Breast cancer; Positron emission tomography; Cancer; Cancer research; Immunohistochemistry; Annexin; Annexin A5; Pathology; Oncology; Internal medicine; Nuclear medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006231851,0.0007477169,0.0005619442,0.0005982569,0.00007644943,0.000486785,0.0002401638,0.0005600642,0.0007934357],"category_scores_gemma":[0.0006190072,0.000213142,0.0001606159,0.000308261,0.0001769063,0.0003535471,0.0001545575,0.0006372115,0.000359737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004230062,"about_ca_system_score_gemma":0.0002385874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004139468,"about_ca_topic_score_gemma":0.0007217973,"domain_scores_codex":[0.9997018,0.00005571526,0.00001710653,0.00005218947,0.0001317862,0.00004133242],"domain_scores_gemma":[0.9996789,0.00005775563,0.000150354,0.00001933472,0.00005819785,0.00003552356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002095616,0.0008497101,0.0277309,0.0002326789,0.00008488382,0.00008414947,0.00003630071,0.00160353,0.93972,0.00006325102,0.0003922921,0.02710662],"study_design_scores_gemma":[0.0002000245,0.007326072,0.1410028,0.0000437802,0.0003071376,0.0008265615,0.0001098482,0.01471993,0.831522,0.0001630592,0.003746473,0.00003231538],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986289,0.006762132,0.004981029,0.0001599922,0.00003135931,0.0001195706,0.0005905325,0.0001942011,0.0008722228],"genre_scores_gemma":[0.9903066,0.002371802,0.004436284,0.0001094749,0.00003303164,0.0001653688,0.0008500032,0.00002191427,0.001705452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007934357,"threshold_uncertainty_score":0.00329572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3413549984427097,"score_gpt":0.6007117179825404,"score_spread":0.2593567195398307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}