{"id":"W2105401953","doi":"10.1158/1541-7786.mcr-14-0246","title":"Hypoxia Provokes Base Excision Repair Changes and a Repair-Deficient, Mutator Phenotype in Colorectal Cancer Cells","year":2014,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"MUTYH; Base excision repair; DNA glycosylase; DNA repair; Biology; DNA damage; Molecular biology; Cancer research; Clonogenic assay; DNA mismatch repair; Gene silencing; Gene; DNA; Genetics; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006350547,0.0002365739,0.0002490361,0.00009640622,0.0001333623,0.0001419482,0.0001091481,0.0002401132,0.001510425],"category_scores_gemma":[0.00006883564,0.00009303089,0.0001387399,0.0001261292,0.0001171354,0.0001053638,0.0001487685,0.0002464628,0.0004093971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002296612,"about_ca_system_score_gemma":0.0001247348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001296585,"about_ca_topic_score_gemma":0.001186986,"domain_scores_codex":[0.9999132,0.00001114038,0.00001097318,0.00001900639,0.00002176699,0.00002386977],"domain_scores_gemma":[0.9999089,0.00001315684,0.00002814488,0.00001060162,0.00001084593,0.0000283161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001979896,0.00001955927,0.0003761009,0.00003454562,0.000003570123,0.0001009671,0.0000158012,0.00001493513,0.9987525,0.0000137941,0.00004276703,0.0004274355],"study_design_scores_gemma":[0.0000353648,0.001612841,0.05622417,0.00001143969,0.00003077447,0.001769692,0.0001014954,0.0006956526,0.9350302,0.00003372447,0.004447087,0.000007607233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962595,0.001363356,0.0009310432,0.00007284647,0.00003266034,0.00002171131,0.0006238062,0.00005782481,0.0006373107],"genre_scores_gemma":[0.9954822,0.0006286905,0.000806024,0.0000603544,0.00001466789,0.00003862423,0.0009670868,0.00001221412,0.001990151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001510425,"threshold_uncertainty_score":0.005052805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02404455773343226,"score_gpt":0.3254099929459224,"score_spread":0.3013654352124901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}