{"id":"W2105427659","doi":"10.1242/dev.049494","title":"Distinct functions of BMP4 during different stages of mouse ES cell neural commitment","year":2010,"lang":"en","type":"article","venue":"Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Key Research and Development Program of China; Shanghai Municipal People's Government; National Natural Science Foundation of China","keywords":"Epiblast; Biology; Embryonic stem cell; Cell biology; Bone morphogenetic protein 4; Germ layer; Neural stem cell; Neural development; Bone morphogenetic protein; Neural crest; Stem cell; Embryo; Genetics; Induced pluripotent stem cell; Embryogenesis; Gene; Gastrulation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009145682,0.0001256365,0.0001448221,0.00005429841,0.00006834769,0.000007231694,0.0001855987,0.00006610656,0.0000636413],"category_scores_gemma":[0.00001890961,0.0001056798,0.0000560915,0.00004519328,0.00007134378,0.000002011849,0.0002488932,0.0001064314,0.000006854174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000153071,"about_ca_system_score_gemma":0.00006108698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008025764,"about_ca_topic_score_gemma":0.00007640406,"domain_scores_codex":[0.9990628,0.00002966551,0.0002687353,0.0002086233,0.0002238853,0.0002063198],"domain_scores_gemma":[0.9994481,0.00001163037,0.0000929911,0.0002883665,0.00008113142,0.0000777427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000428507,0.0002215584,0.05105218,0.0001067933,0.00003829712,0.000001385493,0.00006451219,0.0000148612,0.947702,0.000005617474,0.0001675159,0.000582464],"study_design_scores_gemma":[0.0003611293,0.00006198323,0.1605248,0.000005677117,0.000004953774,0.000001593744,0.00004279429,0.000009783368,0.8360372,0.000001050371,0.002857217,0.00009186329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989592,0.00006854529,0.0001192636,0.00003301367,0.0001273771,0.0001848604,0.00003128181,0.00000670902,0.0004697189],"genre_scores_gemma":[0.9933894,0.00002225348,0.0005758473,0.000005259648,0.00002674063,0.00002993889,0.0001192146,0.00001381879,0.005817572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1116648,"threshold_uncertainty_score":0.4309499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01213480923723889,"score_gpt":0.240985050139012,"score_spread":0.2288502409017731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}