{"id":"W2105434359","doi":"10.1124/dmd.107.015479","title":"Mutational Analysis of a Highly Conserved Proline Residue in MRP1, MRP2, and MRP3 Reveals a Partially Conserved Function","year":2007,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Multidrug resistance-associated protein 2; Mutant; ATP-binding cassette transporter; Efflux; Vanadate; Transport protein; Chemistry; Wild type; ATP hydrolysis; Biochemistry; Transporter; Biology; Enzyme; ATPase; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002905825,0.0007311364,0.0005089229,0.0002907912,0.0004723789,0.0003677743,0.0004893923,0.0008134766,0.001397021],"category_scores_gemma":[0.0004771359,0.0001582454,0.000747703,0.0002389467,0.0005879618,0.0002227024,0.0003267724,0.000763956,0.0007045053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004567707,"about_ca_system_score_gemma":0.0004348931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001326429,"about_ca_topic_score_gemma":0.001158061,"domain_scores_codex":[0.9997758,0.00005897422,0.000025082,0.00003935167,0.00006162829,0.00003916245],"domain_scores_gemma":[0.9994572,0.0001398822,0.0001428372,0.00005112955,0.00008008683,0.0001288334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009396733,0.0001153356,0.003154202,0.0001084667,0.00009970108,0.005626648,0.0000924243,0.001215101,0.9827678,0.0009696987,0.0002723188,0.004638636],"study_design_scores_gemma":[0.0002115769,0.001569609,0.03780092,0.00005390666,0.0003046489,0.02032503,0.0002004141,0.009972335,0.92352,0.0006156966,0.005320638,0.0001053004],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896001,0.0004271047,0.007821306,0.0002175703,0.00007589871,0.00005710272,0.0004496496,0.0001259208,0.00122551],"genre_scores_gemma":[0.9954877,0.00012634,0.00336766,0.0001114874,0.00001950071,0.0000163181,0.000321049,0.00002763547,0.0005223402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001397021,"threshold_uncertainty_score":0.004673481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007970663902696021,"score_gpt":0.2455084522934663,"score_spread":0.2375377883907703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}