{"id":"W2105434359","doi":"10.1124/dmd.107.015479","title":"Mutational Analysis of a Highly Conserved Proline Residue in MRP1, MRP2, and MRP3 Reveals a Partially Conserved Function","year":2007,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Multidrug resistance-associated protein 2; Mutant; ATP-binding cassette transporter; Efflux; Vanadate; Transport protein; Chemistry; Wild type; ATP hydrolysis; Biochemistry; Transporter; Biology; Enzyme; ATPase; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000923795,0.0001694459,0.0005938885,0.0005633172,0.0000681134,0.00001626734,0.00003202077,0.0001056768,0.00002982111],"category_scores_gemma":[0.00003257646,0.0001454495,0.0001129416,0.0007529272,0.0001176915,0.0001389955,0.00001077648,0.0001134493,9.525294e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001515158,"about_ca_system_score_gemma":0.0000585993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003130889,"about_ca_topic_score_gemma":0.002436176,"domain_scores_codex":[0.9985,0.00007446853,0.0005943314,0.0003176707,0.0002892494,0.0002242219],"domain_scores_gemma":[0.9992735,0.00009486787,0.0001760918,0.0001544601,0.0001610272,0.0001400862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01530097,0.001229694,0.3054495,0.0009702266,0.001790421,0.0003340614,0.003739635,0.0001383536,0.6230327,0.04257984,0.0001726484,0.005261898],"study_design_scores_gemma":[0.003136188,0.0000586799,0.9694003,0.0001014564,0.0026199,0.00001217592,0.0003051408,0.0006325583,0.022018,0.001426277,0.0001393592,0.0001499773],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930592,0.00212255,0.003270193,0.0006500852,0.00008081352,0.0004414928,0.00007581323,0.00003121203,0.0002686604],"genre_scores_gemma":[0.9975551,0.0001777779,0.0009874941,0.0003533069,0.000067212,0.00002333421,0.0005749277,0.0000130875,0.0002477633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6639508,"threshold_uncertainty_score":0.5931259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007970663902696021,"score_gpt":0.2455084522934663,"score_spread":0.2375377883907703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}