{"id":"W2105437330","doi":"10.1128/iai.01789-06","title":"A Defined O-Antigen Polysaccharide Mutant of<i>Francisella tularensis</i>Live Vaccine Strain Has Attenuated Virulence while Retaining Its Protective Capacity","year":2007,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Institute for Biological Sciences","funders":"U.S. Food and Drug Administration; National Institute of Allergy and Infectious Diseases; Centers for Disease Control and Prevention","keywords":"Francisella tularensis; Virulence; Attenuated vaccine; Microbiology; Tularemia; Biology; Virology; Mutant; Pathogen; Immune system; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009349325,0.0002534931,0.0001729966,0.0001119266,0.0000815264,0.0001371741,0.0002026698,0.000216355,0.0004699395],"category_scores_gemma":[0.0001755566,0.00007080997,0.0001535024,0.0000860635,0.0002118969,0.0001071011,0.0001278338,0.0002839578,0.0002008854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002067499,"about_ca_system_score_gemma":0.0001785929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001296177,"about_ca_topic_score_gemma":0.001336015,"domain_scores_codex":[0.9999107,0.00001466316,0.00001088437,0.00001520188,0.00002547415,0.00002306337],"domain_scores_gemma":[0.9998777,0.0000236822,0.00004734722,0.00001441748,0.00001364396,0.00002323937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004275121,0.00002960448,0.0001499177,0.0000100608,0.000002328704,0.00002152683,0.000006308846,0.00003796798,0.9992086,0.0000644857,0.00001194769,0.0004144615],"study_design_scores_gemma":[0.00001842782,0.0008295141,0.004692063,0.000006958583,0.00001577841,0.0005187015,0.00003197592,0.001363019,0.9912962,0.00004035352,0.001180752,0.000006212699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980322,0.0001304359,0.001351214,0.00003477799,0.000008060214,0.000008880096,0.00008204843,0.00002469294,0.0003276581],"genre_scores_gemma":[0.9967084,0.0001059269,0.00185206,0.00002126409,0.000005133979,0.00001125981,0.0005472879,0.00001742128,0.000731253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001296177,"threshold_uncertainty_score":0.002577245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03668214003129684,"score_gpt":0.2639548424454046,"score_spread":0.2272727024141078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}