{"id":"W2105437330","doi":"10.1128/iai.01789-06","title":"A Defined O-Antigen Polysaccharide Mutant of<i>Francisella tularensis</i>Live Vaccine Strain Has Attenuated Virulence while Retaining Its Protective Capacity","year":2007,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Institute for Biological Sciences","funders":"U.S. Food and Drug Administration; National Institute of Allergy and Infectious Diseases; Centers for Disease Control and Prevention","keywords":"Francisella tularensis; Virulence; Attenuated vaccine; Microbiology; Tularemia; Biology; Virology; Mutant; Pathogen; Immune system; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001072956,0.0001921495,0.0002547286,0.00009970026,0.0003097551,0.00003933981,0.0001082424,0.0002156105,0.00006852576],"category_scores_gemma":[0.0004659094,0.0001817335,0.00009324867,0.0002559995,0.0001352851,0.00001559444,0.0001186554,0.0003004647,0.000008292924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002701045,"about_ca_system_score_gemma":0.00008577312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001474071,"about_ca_topic_score_gemma":0.0004956872,"domain_scores_codex":[0.9986803,0.0001769873,0.0003385321,0.0002999663,0.0001634778,0.0003407485],"domain_scores_gemma":[0.9989831,0.00004214868,0.0001621655,0.0002919898,0.0003986791,0.0001219557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004376215,0.00008168385,0.005794491,0.00003738899,0.00007582307,0.000002117639,0.0003622816,0.000006409814,0.9850152,0.00003524276,0.00001209291,0.00813966],"study_design_scores_gemma":[0.0008884111,0.0005251867,0.1275249,0.00003902395,0.00001735708,0.00003540863,0.0001122478,0.0000959883,0.8693557,0.00008230696,0.001116706,0.0002067599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944829,0.0002854496,0.004178274,0.00004276376,0.000115994,0.0004210871,0.00008000555,0.00002278542,0.0003707568],"genre_scores_gemma":[0.999317,0.0003475809,0.000102056,0.00005296989,0.00008502685,0.00001355899,0.00004053172,0.00001855379,0.00002264886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1217304,"threshold_uncertainty_score":0.7410877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03668214003129684,"score_gpt":0.2639548424454046,"score_spread":0.2272727024141078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}