{"id":"W2105464215","doi":"10.1093/protein/gzs055","title":"Disulfide linkage engineering for improving biophysical properties of human VH domains","year":2012,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; University of Guelph; National Research Council Canada","funders":"","keywords":"Linkage (software); Disulfide bond; Disulfide Linkage; Chemistry; Computational biology; Combinatorial chemistry; Biochemistry; Biology; Cysteine; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003090335,0.0002680196,0.0001291237,0.0001632725,0.0001252272,0.0001921745,0.0001521578,0.0001971361,0.0006397683],"category_scores_gemma":[0.0002365229,0.0001003706,0.0001960749,0.000189992,0.00009884554,0.0001504215,0.0001684244,0.0003193229,0.0001679914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002109551,"about_ca_system_score_gemma":0.0001142286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002133535,"about_ca_topic_score_gemma":0.0003234124,"domain_scores_codex":[0.9999064,0.00003027848,0.000008769038,0.000016392,0.00002536481,0.00001272034],"domain_scores_gemma":[0.9999332,0.00001630656,0.00002027757,0.000005641511,0.0000119044,0.00001264626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002766549,0.00001532703,0.0001148513,0.00001330408,0.00000302749,0.00001499609,0.00001160506,0.0001555956,0.9981329,0.00009071174,0.00002098182,0.001399059],"study_design_scores_gemma":[0.000009166167,0.0001519495,0.000890373,0.000003010997,0.000009365173,0.00014461,0.00001035278,0.001153326,0.9948545,0.00005561293,0.002714576,0.000003250955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886882,0.0007387878,0.00951604,0.0001015057,0.00001702286,0.0000254011,0.00008431459,0.00003322179,0.0007955673],"genre_scores_gemma":[0.9834335,0.0008626811,0.01377422,0.00007688801,0.00001137449,0.00002187545,0.0003051927,0.00002592365,0.001488404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006397683,"threshold_uncertainty_score":0.002140224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01903967436920555,"score_gpt":0.2235577712318803,"score_spread":0.2045180968626747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}