{"id":"W2105516896","doi":"10.1093/carcin/bgu049","title":"Combination of AKT inhibition with autophagy blockade effectively reduces ascites-derived ovarian cancer cell viability","year":2014,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Autophagy; Protein kinase B; PI3K/AKT/mTOR pathway; Viability assay; Cancer research; Cancer cell; Cell growth; Biology; Downregulation and upregulation; Chemistry; Cell; Signal transduction; Pharmacology; Cell biology; Cancer; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001585428,0.0003331647,0.0005103034,0.0002970466,0.000130393,0.0002395331,0.0001747265,0.0001733862,0.0008052833],"category_scores_gemma":[0.0001214491,0.000115781,0.0002568146,0.0002479403,0.0001792232,0.0001538605,0.0002085734,0.0005310607,0.0002143302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002590604,"about_ca_system_score_gemma":0.0004109232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004913824,"about_ca_topic_score_gemma":0.001086685,"domain_scores_codex":[0.9998618,0.00002267282,0.00001884146,0.00002188541,0.00004357662,0.0000310963],"domain_scores_gemma":[0.9999223,0.00001673975,0.00001377145,0.00001337811,0.000007317536,0.00002645757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007855037,0.000375774,0.0007682502,0.0001096593,0.00003466464,0.00007745205,0.00003430165,0.0006267535,0.9858488,0.0001587588,0.0003405821,0.01083945],"study_design_scores_gemma":[0.0001428596,0.003221437,0.007812616,0.000007880412,0.0000477836,0.0003108462,0.00002571297,0.002492047,0.9820966,0.00007045907,0.003761502,0.00001039414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947556,0.001871056,0.001018949,0.0001012523,0.0000478274,0.00006396059,0.000339797,0.0001185054,0.001683027],"genre_scores_gemma":[0.9966083,0.0008730546,0.001119354,0.00003454739,0.00001169547,0.0000427912,0.0003983557,0.0000126944,0.0008993375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008052833,"threshold_uncertainty_score":0.002693951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009238823520365253,"score_gpt":0.2445169041405713,"score_spread":0.2352780806202061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}