{"id":"W2105516896","doi":"10.1093/carcin/bgu049","title":"Combination of AKT inhibition with autophagy blockade effectively reduces ascites-derived ovarian cancer cell viability","year":2014,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Autophagy; Protein kinase B; PI3K/AKT/mTOR pathway; Viability assay; Cancer research; Cancer cell; Cell growth; Biology; Downregulation and upregulation; Chemistry; Cell; Signal transduction; Pharmacology; Cell biology; Cancer; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002422246,0.0001945719,0.0003881289,0.00008087429,0.00008620015,0.000009330079,0.00006571408,0.0001080569,0.0002204303],"category_scores_gemma":[0.00004429526,0.0001575749,0.0001194702,0.0002358917,0.0001422773,0.00009981453,0.00001997524,0.00007614402,0.000006358713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001453185,"about_ca_system_score_gemma":0.0001521322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004322577,"about_ca_topic_score_gemma":0.00001986635,"domain_scores_codex":[0.9987292,0.0001685892,0.0002454,0.0003508121,0.0002973592,0.0002086174],"domain_scores_gemma":[0.998978,0.0001075645,0.0001689561,0.0003324433,0.0002732172,0.0001398845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005918524,0.0004939246,0.0352045,0.0002984854,0.0001126965,0.000007867274,0.0004155452,0.00003451042,0.9557177,0.0001399103,0.00003239615,0.006950581],"study_design_scores_gemma":[0.00204542,0.0004259957,0.3986182,0.00006604654,0.0001799027,0.000003833619,0.00003983623,0.0002142177,0.59813,0.0001495129,0.00002887355,0.00009811407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964303,0.0008905308,0.0005635589,0.0001817468,0.0001040328,0.0006046487,0.00002256091,0.00007756901,0.001125057],"genre_scores_gemma":[0.9991255,0.00004749475,0.0002440372,0.0001718757,0.0001265514,0.000117834,0.00003883185,0.00003242608,0.00009548331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3634137,"threshold_uncertainty_score":0.6425718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009238823520365253,"score_gpt":0.2445169041405713,"score_spread":0.2352780806202061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}