{"id":"W2105541548","doi":"10.1097/cmr.0000000000000141","title":"LINE-1 hypermethylation in peripheral blood of cutaneous melanoma patients is associated with metastasis","year":2015,"lang":"en","type":"article","venue":"Melanoma Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"CDKN2A; DNA methylation; Epigenetics; Methylation; CpG site; Melanoma; Biomarker; Cancer research; Medicine; Metastasis; Cancer; Oncology; Biology; Internal medicine; DNA; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009913496,0.0001538121,0.0002462101,0.0004663955,0.0001864095,0.0002432769,0.0001073717,0.0002089831,0.001827967],"category_scores_gemma":[0.0006702448,0.0001428301,0.00008857212,0.0003862926,0.00009568225,0.0001260597,0.0001058826,0.0002416313,0.0002164509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008091894,"about_ca_system_score_gemma":0.00005656559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005150913,"about_ca_topic_score_gemma":0.0005868812,"domain_scores_codex":[0.9998937,0.00002276396,0.000009878989,0.00004266232,0.00001783852,0.0000130972],"domain_scores_gemma":[0.9997066,0.00006336451,0.0001284487,0.00002106173,0.00003053885,0.00005005818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008553555,0.00007046737,0.9219869,0.0000428659,0.00006764242,0.0008771822,0.0001687491,0.00008080626,0.06567848,0.0000332449,0.000195398,0.009942858],"study_design_scores_gemma":[0.000008989539,0.0001813698,0.9925235,0.000004981502,0.00003426884,0.003183862,0.00006876194,0.0002646259,0.003423507,0.00003736708,0.0002651964,0.000003703004],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992118,0.0002776877,0.0001639719,0.00001265471,0.000002411249,0.000002909207,0.0001014908,0.000009392737,0.0002175889],"genre_scores_gemma":[0.9995064,0.00008071707,0.0001298436,0.000009558602,0.000004175024,0.000003179767,0.00009734165,0.000002120018,0.000166724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001827967,"threshold_uncertainty_score":0.006115139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05605349334458096,"score_gpt":0.3259420169825973,"score_spread":0.2698885236380163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}