{"id":"W2105541548","doi":"10.1097/cmr.0000000000000141","title":"LINE-1 hypermethylation in peripheral blood of cutaneous melanoma patients is associated with metastasis","year":2015,"lang":"en","type":"article","venue":"Melanoma Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"CDKN2A; DNA methylation; Epigenetics; Methylation; CpG site; Melanoma; Biomarker; Cancer research; Medicine; Metastasis; Cancer; Oncology; Biology; Internal medicine; DNA; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009367817,0.000131554,0.0002044705,0.0001744768,0.00004937297,0.00002390585,0.0001855094,0.0001518288,0.00002600812],"category_scores_gemma":[0.0006308309,0.0001142228,0.00004650304,0.0003973322,0.0001017766,0.0000064734,0.000101717,0.0001728401,0.000005127274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005125055,"about_ca_system_score_gemma":0.0001772097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001756208,"about_ca_topic_score_gemma":0.0003003714,"domain_scores_codex":[0.9980809,0.0003424989,0.0002858745,0.0003331205,0.0006180113,0.0003395761],"domain_scores_gemma":[0.9985852,0.00005516924,0.0000950153,0.0003075463,0.0008350706,0.0001220535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006691716,0.0009221653,0.7304254,0.00002536856,0.0002486454,0.0000472566,0.0006825364,0.0005052977,0.2586834,0.0000316806,0.0002139838,0.00754518],"study_design_scores_gemma":[0.003785627,0.005727543,0.06868983,0.00003776313,0.00004404331,0.000007111228,0.0002360282,0.0004839422,0.9183271,0.0003594596,0.001994675,0.0003069059],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996949,0.000780321,0.00007709843,0.00006407327,0.00004205387,0.0002776156,0.0000450007,0.000005100131,0.00175977],"genre_scores_gemma":[0.9986348,0.00007593733,0.0004370625,0.00001262511,0.00005581196,0.0000226169,0.00025421,0.00002680745,0.000480111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6617355,"threshold_uncertainty_score":0.4657871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05605349334458096,"score_gpt":0.3259420169825973,"score_spread":0.2698885236380163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}