{"id":"W2105555171","doi":"10.1021/jo060552l","title":"Synthesis of Substituted Benzoxacycles via a Domino Ortho-Alkylation/Heck Coupling Sequence","year":2006,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Domino; Heck reaction; Alkylation; Sequence (biology); Coupling (piping); Combinatorial chemistry; Organic chemistry; Palladium; Stereochemistry; Catalysis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001314916,0.0003717983,0.0006784366,0.00003641521,0.0001543723,0.00003330741,0.001099766,0.0002947578,0.006421828],"category_scores_gemma":[0.001302512,0.0002945492,0.0002769686,0.0003788165,0.0003696407,0.0001343908,0.0001412216,0.0006380749,0.000009832655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000285523,"about_ca_system_score_gemma":0.0004000497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004109429,"about_ca_topic_score_gemma":0.000003927807,"domain_scores_codex":[0.9971308,0.0000395432,0.00143109,0.0002553883,0.0007521963,0.0003910571],"domain_scores_gemma":[0.9954708,0.001440048,0.001701447,0.0008397338,0.0004055273,0.0001424594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001158686,0.0001371783,0.001092059,0.0003396506,0.0001370654,0.0000281345,0.00009100709,0.0002373614,0.9969531,0.000005669971,0.00007767276,0.0007851809],"study_design_scores_gemma":[0.0006119679,0.000005476901,0.0002185184,0.0003319799,0.000424133,0.001498299,0.0003727807,0.0003526053,0.9951949,0.0004392365,0.0002635492,0.0002865716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916645,0.0009110895,0.002399402,0.0002675189,0.00008308964,0.00004628662,0.00002556353,0.00004966904,0.004552825],"genre_scores_gemma":[0.9958161,0.0001179778,0.003001822,0.000008158535,0.000594057,0.000002174962,0.000006704061,0.00007024575,0.0003827964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006411995,"threshold_uncertainty_score":0.9999506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01580957810242483,"score_gpt":0.2523057268141271,"score_spread":0.2364961487117022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}