{"id":"W2105567749","doi":"10.1002/anie.200903112","title":"Biomimetic Nanocarrier for Direct Cytosolic Drug Delivery","year":2009,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":155,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"Nanocarriers; Cytosol; Schematic; Chemistry; Scavenger; Phospholipid; Drug delivery; Computer science; Biophysics; Nanotechnology; Membrane; Biochemistry; Biology; Materials science; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001081817,0.000144176,0.0001076323,0.00006582027,0.00006507573,0.00004158156,0.0002177652,0.0001028205,0.00007497049],"category_scores_gemma":[0.00007307396,0.0001440024,0.0001524058,0.00004995482,0.00003565641,0.00001776947,0.00003072282,0.00004928215,0.00002368912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003593274,"about_ca_system_score_gemma":0.00004464086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001338034,"about_ca_topic_score_gemma":0.00001175514,"domain_scores_codex":[0.9991421,0.00001041174,0.0001844485,0.0003142216,0.0001508682,0.0001979509],"domain_scores_gemma":[0.9994262,0.00001612291,0.00007830354,0.0001695338,0.000244352,0.00006550172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001506027,0.00005684118,0.00010358,0.000004369108,0.00005925585,0.000001610197,0.00003107277,0.000007639399,0.9053022,0.00003838752,0.09160594,0.002638502],"study_design_scores_gemma":[0.0004875807,0.0001668394,0.0004799578,0.00002214288,0.00001971303,0.000008905816,0.00002876128,0.00003703354,0.9199259,0.000569726,0.07808784,0.000165582],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746626,0.0006349295,0.004448366,0.001831926,0.0018913,0.0002819897,0.0003105977,0.00004758043,0.0158907],"genre_scores_gemma":[0.9917868,0.0002827952,0.0003358435,0.00152441,0.002209749,0.00004778349,0.001629467,0.00001357675,0.002169566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01712419,"threshold_uncertainty_score":0.5872247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01040546932648803,"score_gpt":0.2567665822395821,"score_spread":0.2463611129130941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}