{"id":"W2105567749","doi":"10.1002/anie.200903112","title":"Biomimetic Nanocarrier for Direct Cytosolic Drug Delivery","year":2009,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":155,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"Nanocarriers; Cytosol; Schematic; Chemistry; Scavenger; Phospholipid; Drug delivery; Computer science; Biophysics; Nanotechnology; Membrane; Biochemistry; Biology; Materials science; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001981912,0.0003461944,0.000336478,0.000198052,0.000185153,0.000444366,0.0003289635,0.0007824218,0.0008357017],"category_scores_gemma":[0.0002814721,0.000197429,0.0002646127,0.0001337938,0.0002537639,0.0004578391,0.0003923829,0.000771057,0.0006622798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000642918,"about_ca_system_score_gemma":0.0003880293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005297889,"about_ca_topic_score_gemma":0.0006202107,"domain_scores_codex":[0.9998647,0.00001375607,0.00001329622,0.00004078319,0.00004368268,0.00002376944],"domain_scores_gemma":[0.9998966,0.00002031905,0.00002762576,0.00001447259,0.00002277506,0.00001812347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000188201,0.000009885337,0.00001296408,0.00005700131,0.000003584984,0.00002661523,0.00001324983,0.0001101285,0.9967552,0.0003530499,0.00009460686,0.002544947],"study_design_scores_gemma":[0.00001187602,0.00005402636,0.00006620881,0.000003671127,0.000005603878,0.0000689182,0.000002872364,0.0008979863,0.9958021,0.00004300338,0.00303854,0.000005163357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8143713,0.0106308,0.1617001,0.00151377,0.0004854196,0.0004518506,0.0006949002,0.001548028,0.008603808],"genre_scores_gemma":[0.9060119,0.003038365,0.08048256,0.0005076235,0.00005597833,0.0002623518,0.0003346159,0.00009339341,0.009213218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008357017,"threshold_uncertainty_score":0.00466466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01040546932648803,"score_gpt":0.2567665822395821,"score_spread":0.2463611129130941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}