{"id":"W2105612180","doi":"10.1110/ps.062728407","title":"Development of indole chemistry to label tryptophan residues in protein for determination of tryptophan surface accessibility","year":2007,"lang":"en","type":"article","venue":"Protein Science","topic":"Mass Spectrometry Techniques and Applications","field":"Chemistry","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Heritage Foundation for Medical Research","keywords":"Tryptophan; Chemistry; Indole test; Reactivity (psychology); Anthranilic acid; Carbonic anhydrase; Accessible surface area; Trypsin; Organic chemistry; Amino acid; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002601329,0.0004819609,0.0001570773,0.0002472628,0.0001524796,0.000169293,0.0003582668,0.0003897881,0.0006466524],"category_scores_gemma":[0.0002273668,0.000179297,0.0002310401,0.0001726089,0.0002043066,0.0001941282,0.0001379334,0.0006115172,0.0003002869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000319555,"about_ca_system_score_gemma":0.0002360519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007455414,"about_ca_topic_score_gemma":0.001645349,"domain_scores_codex":[0.9998643,0.00003186312,0.000005656772,0.00003549936,0.00003791761,0.00002481914],"domain_scores_gemma":[0.9997997,0.00004465968,0.00005468886,0.00002216776,0.00005047696,0.00002829501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007753061,0.000004937644,0.0000332989,0.00001435581,0.000001175078,0.000009795406,0.000003917006,0.00002496578,0.9991164,0.00004599983,0.00001079368,0.0007266171],"study_design_scores_gemma":[0.000003197157,0.00007748543,0.0007587995,0.000003492783,0.000003373018,0.00006934855,0.000004543803,0.000896611,0.997129,0.00003283625,0.001018078,0.000003193241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7648993,0.005076893,0.2252681,0.0002330566,0.0000832542,0.0002103994,0.0004409249,0.0005820342,0.003206103],"genre_scores_gemma":[0.8843244,0.002892753,0.1079871,0.0001360428,0.00002225046,0.0002790416,0.0005859566,0.0000622147,0.003710283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007455414,"threshold_uncertainty_score":0.002318561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02818260647931209,"score_gpt":0.3386224919005794,"score_spread":0.3104398854212673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}