{"id":"W2105612180","doi":"10.1110/ps.062728407","title":"Development of indole chemistry to label tryptophan residues in protein for determination of tryptophan surface accessibility","year":2007,"lang":"en","type":"article","venue":"Protein Science","topic":"Mass Spectrometry Techniques and Applications","field":"Chemistry","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Heritage Foundation for Medical Research","keywords":"Tryptophan; Chemistry; Indole test; Reactivity (psychology); Anthranilic acid; Carbonic anhydrase; Accessible surface area; Trypsin; Organic chemistry; Amino acid; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00161865,0.0001243335,0.0001996346,0.0001027895,0.0001013259,0.0000209947,0.0006780045,0.00008628245,0.0001164498],"category_scores_gemma":[0.000371038,0.0001241534,0.00002890126,0.001072669,0.0001831083,0.0001462671,0.0001536901,0.00009455515,6.394719e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002140484,"about_ca_system_score_gemma":0.0002949394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003441792,"about_ca_topic_score_gemma":0.00004648358,"domain_scores_codex":[0.99821,0.000005463801,0.0005932395,0.0004397047,0.0004254857,0.000326134],"domain_scores_gemma":[0.9989517,0.00003885815,0.0002769255,0.0003945566,0.0002409949,0.00009692602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004609557,0.0001815487,0.0009339037,0.0003617913,8.541527e-7,2.132816e-7,0.0002372405,6.040513e-7,0.9783416,0.0005613479,6.154836e-7,0.01933421],"study_design_scores_gemma":[0.0002713173,0.00002283938,0.002555728,0.0001602529,0.00000119816,3.688231e-7,0.0001128924,0.0001307731,0.9942707,0.00223283,0.0001097328,0.0001313146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765706,0.00001626128,0.01944814,0.00004614512,0.000004015094,0.0009382611,0.00001237606,0.00003858682,0.002925621],"genre_scores_gemma":[0.6861692,2.551139e-7,0.31339,0.000002562618,0.00000838766,0.0002367595,0.000002401208,0.000006282398,0.0001841039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2939419,"threshold_uncertainty_score":0.5062828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02818260647931209,"score_gpt":0.3386224919005794,"score_spread":0.3104398854212673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}