{"id":"W2105627373","doi":"10.1371/journal.pone.0041102","title":"Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to TRAIL-Induced Apoptosis","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Apoptosis; GSK-3; Cancer research; Caspase; Biology; Intrinsic apoptosis; Cancer cell; Pancreatic cancer; Glycogen synthase; Chemistry; Programmed cell death; Kinase; Cell biology; Phosphorylation; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001100484,0.0002658435,0.0002891093,0.0002877764,0.0001017264,0.0002709882,0.0001317518,0.0001829406,0.001226457],"category_scores_gemma":[0.00009136357,0.0001263232,0.0003757314,0.0002482322,0.0001439972,0.0001387268,0.0001629052,0.0008127794,0.0003043491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002230841,"about_ca_system_score_gemma":0.0003014354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005727804,"about_ca_topic_score_gemma":0.001287784,"domain_scores_codex":[0.9998896,0.00001837392,0.00001807551,0.00001426541,0.0000307595,0.00002888824],"domain_scores_gemma":[0.9999418,0.00001062515,0.00001331055,0.00001360121,0.000005937968,0.00001462554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002233665,0.00008185602,0.0004668962,0.00008694553,0.00001920814,0.0001260057,0.00002688445,0.0001640158,0.9956129,0.00007788843,0.000171372,0.002942642],"study_design_scores_gemma":[0.00008633198,0.001304307,0.008189678,0.00001628418,0.00003402217,0.000667168,0.00004232279,0.0008704549,0.982866,0.00009491675,0.005818536,0.000009981185],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912073,0.002856986,0.001650214,0.0002222983,0.0001016677,0.000067966,0.0003688403,0.0001775211,0.003347264],"genre_scores_gemma":[0.9936841,0.002341654,0.001366435,0.0001059282,0.0000132157,0.00005386566,0.0006657467,0.00001291469,0.001756082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001226457,"threshold_uncertainty_score":0.004102886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03040700455279465,"score_gpt":0.2360013191540503,"score_spread":0.2055943146012557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}