{"id":"W2105630217","doi":"10.1099/vir.0.009944-0","title":"Investigation of a role for lysine residues in non-structural proteins 2 and 2/3 of the hepatitis C virus for their degradation and virus assembly","year":2009,"lang":"en","type":"article","venue":"Journal of General Virology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Biology; Replicon; NS3; Viral replication; Protein degradation; NS2-3 protease; Lysine; RNA; Proteasome; Virus; Viral life cycle; Hepatitis C virus; Mutagenesis; Viral protein; Proteolysis; Protease; Cell biology; Virology; Biochemistry; Mutation; DNA; Enzyme; Plasmid; Gene; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005030347,0.00009292897,0.00038827,0.0002038441,0.00004278755,0.000006886311,0.00007946357,0.0001085283,0.000003055799],"category_scores_gemma":[0.0003431569,0.0000600734,0.00007102409,0.000126399,0.0001358765,0.0001157843,0.00002131816,0.0001491412,3.422997e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000389957,"about_ca_system_score_gemma":0.0001258207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007256208,"about_ca_topic_score_gemma":0.00235195,"domain_scores_codex":[0.998947,0.000114539,0.0005120611,0.0001069863,0.0001662969,0.0001531648],"domain_scores_gemma":[0.9990774,0.0001113768,0.0003849706,0.0001055957,0.0002553991,0.00006525658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000703265,0.00001825346,0.1307698,0.00005183607,0.00003161058,0.000001736844,0.0003114134,0.00001676795,0.8534209,0.0001151248,0.00009339384,0.01446593],"study_design_scores_gemma":[0.001667116,0.002068846,0.6336035,0.0000509372,0.0000327273,0.00003786029,0.00001172768,0.003796155,0.3552258,0.003388384,0.00007937312,0.00003762776],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959754,0.000423488,0.0003953966,0.002387859,0.00003834422,0.0007226919,0.00004123068,0.000001529947,0.00001402958],"genre_scores_gemma":[0.9933268,0.0003829909,0.005839815,0.0002631715,0.0001244676,0.00001510028,0.000006857001,0.000008953277,0.00003181967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5028337,"threshold_uncertainty_score":0.2449722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02557959177169401,"score_gpt":0.302587750447055,"score_spread":0.277008158675361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}