{"id":"W2105630217","doi":"10.1099/vir.0.009944-0","title":"Investigation of a role for lysine residues in non-structural proteins 2 and 2/3 of the hepatitis C virus for their degradation and virus assembly","year":2009,"lang":"en","type":"article","venue":"Journal of General Virology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Biology; Replicon; NS3; Viral replication; Protein degradation; NS2-3 protease; Lysine; RNA; Proteasome; Virus; Viral life cycle; Hepatitis C virus; Mutagenesis; Viral protein; Proteolysis; Protease; Cell biology; Virology; Biochemistry; Mutation; DNA; Enzyme; Plasmid; Gene; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001617977,0.0002861431,0.0001465947,0.000085461,0.0001435021,0.0002112662,0.0001896147,0.0002654051,0.0005962452],"category_scores_gemma":[0.0001417497,0.00008846457,0.0002147065,0.00007042525,0.0001808426,0.0002094098,0.00009802898,0.0002191581,0.0002086405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002847923,"about_ca_system_score_gemma":0.0001817789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004951386,"about_ca_topic_score_gemma":0.000328819,"domain_scores_codex":[0.9999396,0.00001376423,0.000005387048,0.0000141821,0.0000150767,0.00001209173],"domain_scores_gemma":[0.9998901,0.00002626864,0.00003482789,0.00001197891,0.00001427731,0.00002251002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002076898,0.00001966859,0.0005654495,0.00003092812,0.000005085874,0.00009241869,0.000009786737,0.00009876612,0.9983072,0.00009010269,0.000007639463,0.000565237],"study_design_scores_gemma":[0.00001294639,0.0004369782,0.01397532,0.000004672062,0.00001822296,0.0007946039,0.00003090355,0.001561046,0.9818696,0.0001015018,0.001187474,0.000006692087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972229,0.001022713,0.001259895,0.00003202336,0.000006274065,0.000007281194,0.00005999195,0.000009438899,0.000379452],"genre_scores_gemma":[0.9975431,0.000398485,0.001255951,0.00002559543,0.000004247644,0.000006038088,0.0001316909,0.000005572263,0.0006292805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005962452,"threshold_uncertainty_score":0.002066314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02557959177169401,"score_gpt":0.302587750447055,"score_spread":0.277008158675361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}