{"id":"W2105635571","doi":"10.1128/mcb.20.22.8623-8633.2000","title":"Cell Signaling Switches HOX-PBX Complexes from Repressors to Activators of Transcription Mediated by Histone Deacetylases and Histone Acetyltransferases","year":2000,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":195,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Medical Research Council; Medical Research Council Canada","keywords":"Biology; Repressor; Hox gene; Corepressor; Transcription factor; Enhancer; Histone deacetylase; Trichostatin A; Cell biology; Coactivator; Psychological repression; Activator (genetics); Retinoic acid; Histone; Genetics; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001140529,0.0002851428,0.0002346532,0.000165268,0.0001844258,0.000530136,0.0002481376,0.0001831454,0.001664046],"category_scores_gemma":[0.0001122626,0.0003845906,0.0001886184,0.000139388,0.000227062,0.0002634578,0.0003519954,0.0005000193,0.0005650258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005470898,"about_ca_system_score_gemma":0.0002172575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000508313,"about_ca_topic_score_gemma":0.001102544,"domain_scores_codex":[0.9997723,0.00002311152,0.00001498932,0.00007000178,0.00005262523,0.0000670009],"domain_scores_gemma":[0.9998987,0.00001507753,0.00002840767,0.00001151958,0.000009802665,0.00003658354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006305079,0.00001111197,0.0003027656,0.00001221029,0.000003775561,0.00002483969,0.00001561379,0.00002956473,0.9983857,0.0002368048,0.00003887011,0.0008756386],"study_design_scores_gemma":[0.00002247915,0.00008273406,0.01227467,0.000005924667,0.0000123528,0.0001438359,0.00005861623,0.001389212,0.9829789,0.0001231191,0.002902227,0.00000597967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945869,0.00112608,0.001974475,0.0000740634,0.00003081891,0.00001121278,0.0001456066,0.00009259841,0.001958171],"genre_scores_gemma":[0.9936698,0.0006167961,0.001293467,0.00006193841,0.00001223489,0.00002124067,0.0003862453,0.00002347064,0.003914886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001664046,"threshold_uncertainty_score":0.005566776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007967738848965749,"score_gpt":0.2528068749694124,"score_spread":0.2448391361204466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}