{"id":"W2105686851","doi":"10.1021/ar000056y","title":"Understanding Nature's Strategies for Enzyme-Catalyzed Racemization and Epimerization","year":2002,"lang":"en","type":"review","venue":"Accounts of Chemical Research","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":197,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Stereocenter; Racemization; Chemistry; Epimer; Stereochemistry; Enzyme; Deprotonation; Mechanism (biology); Stereoselectivity; Catalysis; Enantioselective synthesis; Biochemistry; Philosophy; Organic chemistry; Epistemology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009632366,0.0002297783,0.0007288887,0.0002676925,0.0001239789,0.0002038229,0.0003243883,0.0007246127,0.0001968669],"category_scores_gemma":[0.0009289197,0.0001849719,0.0001115554,0.0004733281,0.0002912446,0.0004179223,0.0001280333,0.000538162,0.00001366733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002118763,"about_ca_system_score_gemma":0.0002247859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009738485,"about_ca_topic_score_gemma":0.000001415255,"domain_scores_codex":[0.9978805,0.0001131471,0.0004717553,0.0004880596,0.0006666908,0.0003798962],"domain_scores_gemma":[0.9980134,0.001054686,0.0002458219,0.0002973681,0.0003142298,0.00007454483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003948447,0.0002238147,0.00000442609,0.08819235,0.0002846238,0.000005773569,0.000622273,0.000009854527,0.4275729,0.1188677,0.02715699,0.3366644],"study_design_scores_gemma":[0.001194197,0.0001665512,6.64646e-7,0.008922375,0.0005221103,0.00003191732,0.000435821,0.0003108743,0.08129603,0.03567589,0.8704444,0.0009991531],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002803279,0.9939614,0.00313824,0.00003496735,0.0002432631,0.0009823918,0.0001182925,0.00003559055,0.001205563],"genre_scores_gemma":[0.01471422,0.9838341,0.0005057582,0.00000779011,0.000329822,0.0001143113,0.0003601485,0.00004938102,0.00008449498],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8432874,"threshold_uncertainty_score":0.7542935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2614653531944267,"score_gpt":0.4301548922040594,"score_spread":0.1686895390096327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}