{"id":"W2105703100","doi":"10.1084/jem.20020077","title":"The Lectin-like Domain of Thrombomodulin Confers Protection from Neutrophil-mediated Tissue Damage by Suppressing Adhesion Molecule Expression via Nuclear Factor κB and Mitogen-activated Protein Kinase Pathways","year":2002,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":349,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Thrombomodulin; Tissue factor; Cell biology; Intercellular Adhesion Molecule-1; Biology; Cell adhesion molecule; Signal transduction; MAPK/ERK pathway; Molecular biology; Thrombin; Chemistry; Immunology; Coagulation; Platelet; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008388774,0.000168448,0.000160298,0.0001302383,0.0000700159,0.000168092,0.0001649929,0.0001779249,0.001045695],"category_scores_gemma":[0.0001118094,0.00008777636,0.0001107033,0.00007635778,0.0001942293,0.0001079799,0.000115948,0.0004620802,0.0001810214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000186024,"about_ca_system_score_gemma":0.0001351316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002085251,"about_ca_topic_score_gemma":0.0003757791,"domain_scores_codex":[0.9999257,0.00001734415,0.000005918035,0.0000126701,0.00001548806,0.00002284237],"domain_scores_gemma":[0.9999137,0.000009208081,0.0000271606,0.000009723892,0.000005513272,0.00003470835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002099541,0.00005504864,0.0001218733,0.00001210398,0.000003188483,0.00002812991,0.000004395883,0.00002375268,0.9985749,0.00008957485,0.00003035746,0.0008466444],"study_design_scores_gemma":[0.0001382601,0.001720325,0.006665353,0.000005233828,0.00002969881,0.0006824664,0.00001881389,0.00119817,0.9860351,0.0001387644,0.003362889,0.000004972497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974169,0.0004430932,0.001224448,0.00007598894,0.0000139753,0.000009073015,0.0001068194,0.00004921549,0.0006604843],"genre_scores_gemma":[0.9972593,0.0002254347,0.0009750773,0.00003686668,0.000008271397,0.00001210049,0.0002440915,0.00000826482,0.001230518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001045695,"threshold_uncertainty_score":0.003498256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03172343889982442,"score_gpt":0.2600996493401969,"score_spread":0.2283762104403724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}