{"id":"W2105718456","doi":"10.1074/jbc.m111.283689","title":"Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase Family","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; National Institute for Health and Care Research; Deutscher Akademischer Austauschdienst; Genome Canada; Directorate for Biological Sciences; Ontario Genomics; Wellcome Trust; Ontario Genomics Institute; Ontario Innovation Trust","keywords":"Demethylase; Histone; Biology; Histone methylation; Biochemistry; Methylation; Epigenetics; Acetylation; Chromatin; Genetics; Gene; DNA methylation; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003676381,0.0001110875,0.0001779439,0.00001270082,0.00009536135,0.000005399509,0.00012774,0.0001842062,0.00002086272],"category_scores_gemma":[0.0002240176,0.00006918806,0.0001316732,0.00004340604,0.0002142177,0.000004025076,0.00004844148,0.0001230486,7.202657e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000139259,"about_ca_system_score_gemma":0.00004930319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009097756,"about_ca_topic_score_gemma":0.000001569927,"domain_scores_codex":[0.9992627,0.00004318617,0.0003276539,0.00014615,0.00008947022,0.0001308309],"domain_scores_gemma":[0.9991983,0.00007188453,0.0003268559,0.0001181789,0.000218768,0.00006600921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002012606,0.00003989792,0.01111707,0.00001884545,0.00006183024,0.000001512792,0.00002435058,0.00001056601,0.987742,0.00001442006,0.00005307148,0.0007151437],"study_design_scores_gemma":[0.000330267,0.0005262342,0.1548063,0.000006451994,0.00003621719,0.00002228949,0.00006636987,0.00002302351,0.8430228,0.0008242776,0.0002501814,0.00008557498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931602,0.005954764,0.0005157478,0.00002802125,0.00005289317,0.00006942784,0.00002527714,0.000002010862,0.0001916127],"genre_scores_gemma":[0.9980274,0.0004170957,0.001268068,0.00001611548,0.0002112554,0.000003450747,0.00001283091,0.000006140053,0.00003761311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1447193,"threshold_uncertainty_score":0.2821407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05046561232251772,"score_gpt":0.2902355046799023,"score_spread":0.2397698923573846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}