{"id":"W2105718456","doi":"10.1074/jbc.m111.283689","title":"Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase Family","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; National Institute for Health and Care Research; Deutscher Akademischer Austauschdienst; Genome Canada; Directorate for Biological Sciences; Ontario Genomics; Wellcome Trust; Ontario Genomics Institute; Ontario Innovation Trust","keywords":"Demethylase; Histone; Biology; Histone methylation; Biochemistry; Methylation; Epigenetics; Acetylation; Chromatin; Genetics; Gene; DNA methylation; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001302296,0.0001579977,0.0002100767,0.0002486486,0.0002097037,0.0002233416,0.0002777631,0.0002797809,0.001255967],"category_scores_gemma":[0.0001979506,0.0001293858,0.0001741733,0.0001997613,0.0002314319,0.0001433771,0.0002271304,0.0002668916,0.0004832609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003079556,"about_ca_system_score_gemma":0.0001889525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000940934,"about_ca_topic_score_gemma":0.0008367076,"domain_scores_codex":[0.9999377,0.00000964329,0.000005687144,0.00002365547,0.0000122415,0.00001109007],"domain_scores_gemma":[0.9999025,0.00001607998,0.00002496461,0.0000154673,0.00001596445,0.00002508673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004499193,0.00003588137,0.009136242,0.00007191877,0.00002606127,0.0005206559,0.00006550052,0.0004343064,0.9811531,0.0009089325,0.000186947,0.007010413],"study_design_scores_gemma":[0.0001196907,0.0004484412,0.1704338,0.00002481149,0.0001416932,0.007877211,0.0001957577,0.007320434,0.7874932,0.001490194,0.0244057,0.0000490848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952633,0.0009844714,0.001827627,0.00008840445,0.00001104837,0.00001112761,0.0002345768,0.00003031499,0.001549161],"genre_scores_gemma":[0.996644,0.0002074011,0.001711315,0.00004798981,0.000006690661,0.000005771265,0.0004647811,0.0000120446,0.0008999811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001255967,"threshold_uncertainty_score":0.004201591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05046561232251772,"score_gpt":0.2902355046799023,"score_spread":0.2397698923573846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}