{"id":"W2105731033","doi":"10.1021/bi0262350","title":"Catalytic Strategy of <i>S</i>-Adenosyl-<scp>l</scp>-homocysteine Hydrolase:  Transition-State Stabilization and the Avoidance of Abortive Reactions","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of General Medical Sciences","keywords":"Chemistry; Hydrolase; Stereochemistry; Substrate (aquarium); Catalysis; Cofactor; Enzyme; Active site; Transition state analog; Substituent; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001513607,0.0002389068,0.0001789095,0.00008976087,0.0001727388,0.0004737306,0.0003590829,0.0002096321,0.0004954311],"category_scores_gemma":[0.0002280159,0.0001327584,0.0001414387,0.00006903995,0.0004382434,0.0002221156,0.0001902141,0.0004891045,0.000182011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004143645,"about_ca_system_score_gemma":0.0002840846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006918082,"about_ca_topic_score_gemma":0.0005517135,"domain_scores_codex":[0.9999176,0.00001515185,0.000005404816,0.00001945425,0.00001922595,0.00002320991],"domain_scores_gemma":[0.9999391,0.00001089168,0.00001315849,0.000007599697,0.000007124211,0.00002212472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001060234,0.00002833339,0.0003640219,0.00003409329,0.000007659734,0.0001062352,0.00004473224,0.0006697826,0.9948561,0.001130573,0.00005803497,0.002594288],"study_design_scores_gemma":[0.00002106169,0.0002110549,0.0007837694,0.000003159038,0.000006684789,0.0002582917,0.00004163837,0.006395418,0.9905466,0.0003068135,0.001415908,0.000009686099],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892564,0.0005633713,0.007661462,0.0001525128,0.00001714318,0.00002823787,0.00003464386,0.0001008788,0.002185446],"genre_scores_gemma":[0.9970836,0.0001269003,0.002349409,0.00001777123,0.000002339481,0.000006887057,0.00003643367,0.00001040431,0.0003662716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006918082,"threshold_uncertainty_score":0.003006518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009646806141048828,"score_gpt":0.2536953765991847,"score_spread":0.2440485704581359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}