{"id":"W2105731033","doi":"10.1021/bi0262350","title":"Catalytic Strategy of <i>S</i>-Adenosyl-<scp>l</scp>-homocysteine Hydrolase:  Transition-State Stabilization and the Avoidance of Abortive Reactions","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of General Medical Sciences","keywords":"Chemistry; Hydrolase; Stereochemistry; Substrate (aquarium); Catalysis; Cofactor; Enzyme; Active site; Transition state analog; Substituent; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002901207,0.0001158629,0.0002532234,0.00004078951,0.00006410985,0.00001064928,0.00005915147,0.00008302489,0.00001357389],"category_scores_gemma":[0.0004473746,0.00008409643,0.00006710907,0.0002982456,0.0004965215,0.00005213232,0.00001004047,0.0001695628,0.000002052063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003011509,"about_ca_system_score_gemma":0.0002315729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008198446,"about_ca_topic_score_gemma":0.000006459135,"domain_scores_codex":[0.9990082,0.00004984656,0.0003271578,0.0001944041,0.0002572344,0.0001631391],"domain_scores_gemma":[0.9990507,0.0002245503,0.0001294263,0.0002894191,0.0002348745,0.0000710348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001321172,0.0002065506,0.0006122062,0.0009653746,0.0001135387,0.00001009473,0.0007953229,0.00005973495,0.9964705,0.0001387883,0.0002559197,0.0002398361],"study_design_scores_gemma":[0.002034516,0.0001044653,0.001289159,0.000135246,0.00008207846,0.00006248322,0.001119953,0.0003551667,0.9942856,0.0001078884,0.0003853379,0.00003806638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932305,0.001932227,0.0001112783,0.0001107127,0.00001505148,0.0002610539,0.0000676175,0.00001268335,0.004258862],"genre_scores_gemma":[0.9974177,0.0004222592,0.00004189393,0.00002202333,0.00002050425,0.00001513742,0.00005778008,0.00001296004,0.001989733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004187195,"threshold_uncertainty_score":0.3429353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009646806141048828,"score_gpt":0.2536953765991847,"score_spread":0.2440485704581359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}