{"id":"W2105731611","doi":"10.1016/j.ahj.2011.09.007","title":"Rationale and design of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist Trial: A randomized, controlled study of spironolactone in patients with symptomatic heart failure and preserved ejection fraction","year":2011,"lang":"en","type":"article","venue":"American Heart Journal","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":275,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Heart Institute","funders":"National Heart, Lung, and Blood Institute","keywords":"Spironolactone; Medicine; Heart failure; Aldosterone; Antagonist; Cardiology; Internal medicine; Randomized controlled trial; Ejection fraction; Eplerenone; Cardiac function curve","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02482413,0.004917221,0.006551956,0.001074198,0.001961217,0.003386011,0.002187423,0.005433018,0.008975867],"category_scores_gemma":[0.01704319,0.002971735,0.003973766,0.0008858053,0.005231163,0.001900765,0.00119509,0.006034332,0.002319791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001206173,"about_ca_system_score_gemma":0.004487487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007535671,"about_ca_topic_score_gemma":0.001211049,"domain_scores_codex":[0.9832721,0.01120636,0.00123381,0.001950415,0.001045201,0.001292136],"domain_scores_gemma":[0.9952211,0.001853477,0.0008090175,0.0006701734,0.0004246363,0.001021625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9641962,0.006199241,0.002721874,0.002486484,0.003541049,0.0001626093,0.0002037615,0.0009242147,0.002612983,0.004119374,0.001821699,0.0110106],"study_design_scores_gemma":[0.9700248,0.01937666,0.001777069,0.0001521636,0.002294203,0.00005333556,0.00003373817,0.0009108867,0.0004049173,0.001674315,0.003250262,0.00004757241],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.3568019,0.01928537,0.02261276,0.01214477,0.0122468,0.556751,0.005535288,0.000715779,0.01390635],"genre_scores_gemma":[0.5313389,0.003278087,0.02980826,0.01042868,0.004220198,0.4143979,0.001821302,0.00008566893,0.004620994],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02482413,"threshold_uncertainty_score":0.1312841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02562535096255576,"score_gpt":0.2536088328157113,"score_spread":0.2279834818531556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}