{"id":"W2105755414","doi":"10.1038/ni.1778","title":"Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori","year":2009,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":438,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"U.S. Public Health Service; National Institutes of Health","keywords":"DC-SIGN; Biology; Acquired immune system; Mycobacterium tuberculosis; Microbiology; Mannose; Pattern recognition receptor; Innate immune system; Cell biology; Virology; Immunology; Dendritic cell; Immune system; Tuberculosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0006308078,0.0007610341,0.0008805677,0.0003334027,0.001094439,0.0001393347,0.001099709,0.001704377,0.0007659455],"category_scores_gemma":[0.000188958,0.0005619817,0.0002864456,0.0007303584,0.0007114704,0.0004173859,0.0002716065,0.003131518,0.0008625397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001442045,"about_ca_system_score_gemma":0.0001047772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009183374,"about_ca_topic_score_gemma":0.000006793863,"domain_scores_codex":[0.9956192,0.001360436,0.0008124835,0.0008294196,0.0001190464,0.001259384],"domain_scores_gemma":[0.9973717,0.0007474894,0.000266695,0.001310147,0.0002555662,0.00004838445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002431457,0.000193422,0.00008727451,0.000008564355,0.0006217653,0.00001589567,0.003141649,0.000009878057,0.9793859,0.002968123,0.002522458,0.008613601],"study_design_scores_gemma":[0.001876909,0.00112234,0.01819411,0.00008755728,0.00009429457,0.0003395158,0.001039339,6.169852e-7,0.5472078,0.001015861,0.4282738,0.0007478433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8639555,0.1218526,0.000212086,0.00963728,0.002431087,0.0008140746,0.00006949531,0.0002497383,0.0007781061],"genre_scores_gemma":[0.9887586,0.003768285,0.0001690686,0.005251717,0.0001843582,0.00007487628,0.0002095124,0.00006839288,0.001515214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4321781,"threshold_uncertainty_score":0.9999154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009265780535470596,"score_gpt":0.2370047202166581,"score_spread":0.2277389396811875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}