{"id":"W2105755884","doi":"10.1083/jcb.200309017","title":"Reversed polarized delivery of an aquaporin-2 mutant causes dominant nephrogenic diabetes insipidus","year":2003,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital du Sacré-Cœur de Montréal","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Aquaporin 2; Nephrogenic diabetes insipidus; Biology; Reabsorption; Apical membrane; Cell biology; Mutant; Vasopressin; Epithelial polarity; Endocrinology; Kidney; Water channel; Genetics; Epithelium; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005590489,0.0001128017,0.0002233665,0.00005321654,0.0000500079,0.000002919419,0.0001818116,0.000150778,0.00002756872],"category_scores_gemma":[0.00002917756,0.00007169796,0.0001259445,0.0000678498,0.0001308317,0.00000613979,0.00001336909,0.0001012984,0.000001452056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008847534,"about_ca_system_score_gemma":0.0001122317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001061692,"about_ca_topic_score_gemma":0.00001513112,"domain_scores_codex":[0.9990134,0.0002586793,0.0003857742,0.00009330084,0.00007498822,0.000173915],"domain_scores_gemma":[0.9991578,0.00002792513,0.0003854688,0.0002007421,0.0001728748,0.00005519018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002870818,0.00006641137,0.0008884406,0.000009198469,0.0000615303,0.000002212904,0.00007742247,0.00003560162,0.998354,0.00004183603,0.00001564705,0.0001606331],"study_design_scores_gemma":[0.0009680022,0.0008701181,0.0006456507,0.000007615089,0.00008926846,0.00003335583,0.0001722014,0.00001200523,0.9910915,0.0002805369,0.005742201,0.00008755724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977784,0.001406209,0.0003051562,0.00002845522,0.0003035817,0.00007417998,0.000006075622,0.000001524046,0.00009646199],"genre_scores_gemma":[0.9987438,0.0007079137,0.0002496428,0.00009256953,0.0001286572,6.543377e-7,0.00002020315,0.00001057756,0.00004600472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007262496,"threshold_uncertainty_score":0.2923758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007932054087190518,"score_gpt":0.2156481325112246,"score_spread":0.2077160784240341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}