{"id":"W2105770902","doi":"10.1093/hmg/ddu361","title":"Whole-exome imputation of sequence variants identified two novel alleles associated with adult body height in African Americans","year":2014,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute on Aging","keywords":"Genome-wide association study; Biology; Genetics; Imputation (statistics); Exome; Exome sequencing; Genetic association; 1000 Genomes Project; Allele; Minor allele frequency; Allele frequency; Single-nucleotide polymorphism; Phenotype; Genotype; Gene; Missing data; Statistics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003144071,0.0006620201,0.001108938,0.0009205815,0.00107521,0.001058671,0.000848316,0.0009265005,0.002733898],"category_scores_gemma":[0.006754769,0.0004436532,0.001828778,0.001944192,0.0003857742,0.0003821462,0.0007795722,0.0009859006,0.0003264464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002973503,"about_ca_system_score_gemma":0.000592077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007616094,"about_ca_topic_score_gemma":0.008888776,"domain_scores_codex":[0.998789,0.000315059,0.0001089288,0.0005235875,0.0001150468,0.0001483617],"domain_scores_gemma":[0.9985518,0.0007351498,0.0002002805,0.0003098067,0.0001159527,0.00008694716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005068181,0.0002798775,0.9072509,0.0002642473,0.003978233,0.00431674,0.001094793,0.006453982,0.03125238,0.001292749,0.003160882,0.03558704],"study_design_scores_gemma":[0.001399885,0.0004647483,0.9531211,0.0001294262,0.00473227,0.00257238,0.0005574115,0.0237366,0.005187913,0.002594085,0.005407164,0.00009688953],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934677,0.0004463907,0.003756279,0.0001643694,0.00001694225,0.00002559605,0.001824008,0.00004573436,0.0002529697],"genre_scores_gemma":[0.9909774,0.0002498209,0.004968881,0.0002112642,0.00002521721,0.00004497348,0.003011101,0.00003648655,0.0004749486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007616094,"threshold_uncertainty_score":0.01662761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01821633521483841,"score_gpt":0.2839095059889233,"score_spread":0.2656931707740849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}