{"id":"W2105774848","doi":"10.1021/bc200233n","title":"Mechanistic Insights into LDL Nanoparticle-Mediated siRNA Delivery","year":2011,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research","funders":"","keywords":"Small interfering RNA; Gene silencing; Chemistry; Endocytosis; Gene knockdown; RNA interference; Internalization; Cell biology; Gene delivery; LDL receptor; Biophysics; Receptor; Molecular biology; Lipoprotein; RNA; Transfection; Gene; Biochemistry; Cholesterol; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008637176,0.0002952102,0.00020049,0.00002859239,0.0001145446,0.0000298973,0.0004138445,0.0002960524,0.0003623252],"category_scores_gemma":[0.00008100865,0.0002837631,0.0001299727,0.0001122739,0.00014764,0.00001030847,0.0002072361,0.0001279647,0.0003173375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002696433,"about_ca_system_score_gemma":0.0001087558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008478142,"about_ca_topic_score_gemma":0.00001789811,"domain_scores_codex":[0.9985272,0.00003007073,0.0003290877,0.0005815262,0.0001531084,0.0003789597],"domain_scores_gemma":[0.9989215,0.00001010593,0.0001145564,0.0005744066,0.000158695,0.0002207941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001510816,0.0001067493,0.0003197497,0.00004705552,0.00007543471,0.00003108541,0.0001809107,9.900323e-7,0.9974292,0.00003220078,0.001161948,0.0004635993],"study_design_scores_gemma":[0.0004825754,0.0001832495,0.0002317364,0.00002612617,0.00003113119,0.00001875287,0.0001857507,0.0000625422,0.9893782,0.0004347689,0.008580741,0.0003844962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928979,0.001117681,0.0001723471,0.00002499324,0.0001800625,0.0001358361,0.00001436715,0.00005430157,0.005402532],"genre_scores_gemma":[0.9972509,0.0003995482,0.0003053781,0.0003831508,0.0002367718,0.00004584789,0.0002105757,0.0000379144,0.001129871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008051065,"threshold_uncertainty_score":0.9999614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01681446679207216,"score_gpt":0.2128362559854114,"score_spread":0.1960217891933393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}