{"id":"W2105774848","doi":"10.1021/bc200233n","title":"Mechanistic Insights into LDL Nanoparticle-Mediated siRNA Delivery","year":2011,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research","funders":"","keywords":"Small interfering RNA; Gene silencing; Chemistry; Endocytosis; Gene knockdown; RNA interference; Internalization; Cell biology; Gene delivery; LDL receptor; Biophysics; Receptor; Molecular biology; Lipoprotein; RNA; Transfection; Gene; Biochemistry; Cholesterol; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003396758,0.0003679533,0.0002984984,0.00015082,0.0002521499,0.0006490601,0.0003942151,0.0007437405,0.001533522],"category_scores_gemma":[0.0002246384,0.0002648654,0.000298569,0.00005702074,0.0003680858,0.0005434238,0.0002686196,0.0006996758,0.0005756313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008885903,"about_ca_system_score_gemma":0.0004705906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000836025,"about_ca_topic_score_gemma":0.0006372264,"domain_scores_codex":[0.9998649,0.00002851658,0.000009688059,0.00002213515,0.00004130291,0.00003337432],"domain_scores_gemma":[0.999936,0.00002431304,0.00001133929,0.000005027117,0.00001437114,0.000008885995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007058915,0.00003913501,0.0001884912,0.0003480775,0.00001332618,0.0004385301,0.00007070638,0.001101577,0.9804823,0.01137093,0.0002586014,0.005617735],"study_design_scores_gemma":[0.00004999283,0.0003025091,0.0007681583,0.00003961043,0.00003257072,0.001034599,0.00008300244,0.013265,0.9648106,0.005083001,0.01450612,0.00002482642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6890813,0.04136369,0.206375,0.007379435,0.0005501255,0.0004242636,0.0007686372,0.0009241883,0.05313336],"genre_scores_gemma":[0.9648918,0.009744929,0.01751627,0.0006831032,0.00003741695,0.000154106,0.0001877989,0.00003816808,0.006746554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001533522,"threshold_uncertainty_score":0.006447196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01681446679207216,"score_gpt":0.2128362559854114,"score_spread":0.1960217891933393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}