{"id":"W2105830018","doi":"10.3324/haematol.2011.044933","title":"Prognostic value of FLT3 mutations in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline monochemotherapy","year":2011,"lang":"en","type":"article","venue":"Haematologica","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"WSP (Canada)","funders":"St. Antonius Ziekenhuis; Universidad de Navarra; Erasmus Universitair Medisch Centrum Rotterdam; Universiteit van Amsterdam; Medisch Spectrum Twente","keywords":"Acute promyelocytic leukemia; Tandem exon duplication; Anthracycline; Gene duplication; Internal medicine; Oncology; Biology; Medicine; Cancer research; Retinoic acid; Immunology; Cancer; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006988308,0.0002214073,0.0003052751,0.00005572261,0.00004537113,0.000009275454,0.0001529126,0.0001667264,0.00001767382],"category_scores_gemma":[0.00003385354,0.0001472887,0.00003157899,0.0001634846,0.0003101101,0.000009197192,0.00002770598,0.0001024704,0.000001026545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001756601,"about_ca_system_score_gemma":0.0001186096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002602917,"about_ca_topic_score_gemma":0.00001456865,"domain_scores_codex":[0.9989024,0.00006055232,0.0002742171,0.0003941884,0.0001257768,0.0002428305],"domain_scores_gemma":[0.9993908,0.00001502358,0.0001595002,0.0002573368,0.0001143869,0.00006289035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002138225,0.0004525558,0.9321442,0.0002032949,0.0003038636,0.0001066017,0.0006554332,0.00002326766,0.06312467,0.0001166314,0.00001751125,0.0007137566],"study_design_scores_gemma":[0.003306498,0.003101558,0.2184081,0.0001282588,0.0001738893,0.0001144017,0.0001140008,0.00009326985,0.7740208,0.000156348,0.00004248766,0.0003404141],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978312,0.0002683693,0.0007893572,0.00002107071,0.000008184149,0.0005589743,0.00001252073,0.00002065365,0.0004896371],"genre_scores_gemma":[0.9939951,0.0001793352,0.005483825,0.00004204718,0.000006868429,0.00007864019,0.0001546717,0.00002548815,0.00003400703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7137361,"threshold_uncertainty_score":0.6006258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009622277325783102,"score_gpt":0.223581109928651,"score_spread":0.2139588326028679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}