{"id":"W2105916116","doi":"10.1158/1055-9965.epi-05-0312","title":"Genetic Polymorphisms of <i>Flavin Monooxygenase 3</i> in Sulindac-Induced Regression of Colorectal Adenomas in Familial Adenomatous Polyposis","year":2005,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Sulindac; Familial adenomatous polyposis; Genotype; Gastroenterology; Internal medicine; Genotyping; Medicine; Flavin-containing monooxygenase; Colorectal cancer; Biology; Genetics; Gene; Monooxygenase; Nonsteroidal; Cytochrome P450; Cancer; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001613214,0.0002990713,0.0011455,0.000544009,0.00003025269,0.000001297673,0.0001550679,0.0004989002,0.00008872907],"category_scores_gemma":[0.0004909789,0.0002610222,0.0002741039,0.0004329556,0.0002124692,0.00009362637,0.00005788718,0.0002875502,0.000007518436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003875749,"about_ca_system_score_gemma":0.0003550326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001408835,"about_ca_topic_score_gemma":0.001460495,"domain_scores_codex":[0.9963791,0.0009127234,0.001511933,0.0005001063,0.0001793276,0.0005167483],"domain_scores_gemma":[0.9982777,0.0004213796,0.0007268656,0.0003358641,0.00006921832,0.0001690205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002418798,0.0002940452,0.7218139,0.0001940892,0.0001117426,0.00003976358,0.0002795215,0.00006668471,0.2437584,0.00002141456,0.0003146981,0.03068693],"study_design_scores_gemma":[0.004152691,0.0006582809,0.9071135,0.001164011,0.0001117521,0.00002804375,0.00007004527,0.001571656,0.08469832,0.0001759148,0.0000553128,0.0002004619],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846503,0.01295039,0.0000614864,0.0007868681,0.0004632404,0.0009863389,0.00001433196,0.00002427441,0.00006280229],"genre_scores_gemma":[0.9963183,0.0008369804,0.00223038,0.0001460361,0.0001837664,0.000170669,0.00003353611,0.00003209337,0.00004822155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1852996,"threshold_uncertainty_score":0.9999842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03057059954521288,"score_gpt":0.3381209897317383,"score_spread":0.3075503901865254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}