{"id":"W2105916116","doi":"10.1158/1055-9965.epi-05-0312","title":"Genetic Polymorphisms of <i>Flavin Monooxygenase 3</i> in Sulindac-Induced Regression of Colorectal Adenomas in Familial Adenomatous Polyposis","year":2005,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Sulindac; Familial adenomatous polyposis; Genotype; Gastroenterology; Internal medicine; Genotyping; Medicine; Flavin-containing monooxygenase; Colorectal cancer; Biology; Genetics; Gene; Monooxygenase; Nonsteroidal; Cytochrome P450; Cancer; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000134549,0.00026391,0.0002552825,0.0003536376,0.0002826643,0.0001572627,0.0001174916,0.0003590124,0.00109815],"category_scores_gemma":[0.0006410763,0.0001752086,0.0003546853,0.0002002182,0.0002034549,0.00008076968,0.0001050309,0.0003457479,0.0001548968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000177688,"about_ca_system_score_gemma":0.00008461264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001586201,"about_ca_topic_score_gemma":0.001603589,"domain_scores_codex":[0.9998646,0.000031552,0.00001911032,0.00003678632,0.00002464254,0.00002336573],"domain_scores_gemma":[0.999632,0.00009777576,0.0001244145,0.00002076207,0.00003076718,0.00009426715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0054777,0.0004677043,0.8758298,0.0000460198,0.0002670542,0.006064979,0.000359244,0.0002892387,0.09953091,0.00007762633,0.0001943537,0.0113953],"study_design_scores_gemma":[0.00008749565,0.001146705,0.9890985,0.000003948816,0.00006931787,0.005333837,0.00005716464,0.0003758651,0.0035235,0.00002596068,0.0002688697,0.000008750078],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996747,0.00007761164,0.00007615653,0.00001321837,0.000002517948,0.000005502327,0.00002896815,0.000004276815,0.0001171871],"genre_scores_gemma":[0.999768,0.00002072206,0.00007393229,0.000009935445,0.000003209408,0.000002514085,0.00003454064,0.000001433967,0.00008583847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001586201,"threshold_uncertainty_score":0.003673673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03057059954521288,"score_gpt":0.3381209897317383,"score_spread":0.3075503901865254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}