{"id":"W2105923514","doi":"10.1016/j.clinthera.2008.09.001","title":"Pharmacokinetic and pharmacodynamic effects of midodrine on blood pressure, the autonomic nervous system, and plasma natriuretic peptides: a prospective, randomized, single-blind, two-period, crossover, placebo-controlled study","year":2008,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Cardiovascular Syncope and Autonomic Disorders","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"Medicine; Midodrine; Crossover study; Blood pressure; Placebo; Atrial natriuretic peptide; Heart rate; Anesthesia; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001783224,0.000467379,0.002445706,0.0001280888,0.0002003796,0.00005123093,0.0002103551,0.0001501241,0.00000989787],"category_scores_gemma":[0.0004178785,0.0003010693,0.0008234154,0.0001765196,0.001153022,0.00005893658,0.0001175187,0.0006145832,0.000007888304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003670754,"about_ca_system_score_gemma":0.0001502151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002483929,"about_ca_topic_score_gemma":0.000003553628,"domain_scores_codex":[0.996223,0.0009959334,0.00131564,0.0006958394,0.0003978995,0.000371628],"domain_scores_gemma":[0.9947803,0.003855515,0.0004539902,0.0006042869,0.0001274752,0.0001784339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8940979,0.008222051,0.01598326,0.001185432,0.04625949,0.000536414,0.003073127,0.001729207,0.004589974,0.0002752116,0.00003218847,0.02401577],"study_design_scores_gemma":[0.9397462,0.002859293,0.003688591,0.00024746,0.0211152,0.0003846392,0.0003493276,0.0301229,0.0006689111,0.00003111536,0.0004240814,0.0003622763],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762992,0.01288143,0.00004982477,0.0001516874,0.0005866453,0.00878654,0.000008604837,0.00009789799,0.001138185],"genre_scores_gemma":[0.9961718,0.002238848,0.00007442942,0.0003639432,0.0002586148,0.0003033794,0.000003157847,0.00007374144,0.0005120284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04564834,"threshold_uncertainty_score":0.9999442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02496074885231027,"score_gpt":0.3187351026004218,"score_spread":0.2937743537481115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}