{"id":"W2105923514","doi":"10.1016/j.clinthera.2008.09.001","title":"Pharmacokinetic and pharmacodynamic effects of midodrine on blood pressure, the autonomic nervous system, and plasma natriuretic peptides: a prospective, randomized, single-blind, two-period, crossover, placebo-controlled study","year":2008,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Cardiovascular Syncope and Autonomic Disorders","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"Medicine; Midodrine; Crossover study; Blood pressure; Placebo; Atrial natriuretic peptide; Heart rate; Anesthesia; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002728293,0.002174373,0.006396998,0.0007706471,0.0008574083,0.001367829,0.001567291,0.002738659,0.003015063],"category_scores_gemma":[0.004336562,0.00202782,0.00186536,0.000809231,0.00335636,0.002558799,0.0006397598,0.003659784,0.00065988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007472137,"about_ca_system_score_gemma":0.001474107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006312157,"about_ca_topic_score_gemma":0.0007847307,"domain_scores_codex":[0.9978041,0.001094115,0.0001893831,0.0003611269,0.0002718724,0.0002793999],"domain_scores_gemma":[0.9969031,0.001085737,0.0005423612,0.0004301859,0.0001607278,0.0008779048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9785497,0.01032425,0.0006136731,0.0001462187,0.0003221503,0.00003141077,0.00004457887,0.0001285663,0.004780168,0.00004290126,0.0001089225,0.004907421],"study_design_scores_gemma":[0.8166049,0.1748267,0.005326646,0.00001262419,0.0004814778,0.00005371823,0.00002107534,0.0004575191,0.001800704,0.00008316727,0.000294699,0.00003675142],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954219,0.001412752,0.0007450826,0.0001486269,0.0001998449,0.001158497,0.0003777267,0.0000594905,0.0004760704],"genre_scores_gemma":[0.9923341,0.001157612,0.001918786,0.0004688388,0.000573651,0.002008714,0.0005060312,0.00003910192,0.0009932509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006396998,"threshold_uncertainty_score":0.01442879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02496074885231027,"score_gpt":0.3187351026004218,"score_spread":0.2937743537481115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}