{"id":"W2105934591","doi":"10.1093/toxsci/kfv051","title":"Characterization of Arsenic Hepatobiliary Transport Using Sandwich-Cultured Human Hepatocytes","year":2015,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Arsenic contamination and mitigation","field":"Environmental Science","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates; Alberta Cancer Foundation","keywords":"Multidrug resistance-associated protein 2; Efflux; Glutathione; Chemistry; Arsenic; Epithelial polarity; Biochemistry; Transporter; ATP-binding cassette transporter; Organic anion transporter 1; Enzyme; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005499221,0.00009023276,0.0001365697,0.00002548786,0.0001777434,0.0000131505,0.0002050331,0.00007598769,0.001257535],"category_scores_gemma":[0.00004928562,0.00006475166,0.00004534247,0.000330515,0.0006331761,0.0003091571,0.00005481157,0.00005359872,0.00003117656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009236736,"about_ca_system_score_gemma":0.00002816299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009556551,"about_ca_topic_score_gemma":0.00009734591,"domain_scores_codex":[0.998869,0.00007479929,0.0002457536,0.000252084,0.0003827489,0.0001755874],"domain_scores_gemma":[0.9996375,0.00001963075,0.0001313209,0.00008063427,0.00001734479,0.0001135517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000006307223,0.00009325385,0.1459687,0.000001649494,0.00000170769,0.000002017101,0.0004663983,0.0001366525,0.8511192,0.0006130284,0.00002033053,0.001570766],"study_design_scores_gemma":[0.0006391998,0.0006215393,0.8182864,0.00001925674,0.00002639834,0.00001434503,0.0006394315,0.01063505,0.1644762,0.002314939,0.001989777,0.0003374995],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929373,0.000006699577,0.0006839547,0.000134395,0.00007297773,0.0001947348,0.000004007104,0.00003893258,0.005926973],"genre_scores_gemma":[0.9986635,0.000003604506,0.000918205,0.0001475288,0.00002047788,0.000006902151,0.0000114144,0.000002531449,0.0002258283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.686643,"threshold_uncertainty_score":0.9996554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08545538939856635,"score_gpt":0.3032264704224094,"score_spread":0.2177710810238431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}