{"id":"W2105945170","doi":"10.1139/o09-172","title":"Structural factors underlying the species barrier and susceptibility to infection in prion diseaseThis paper is one of a selection of papers published in this special issue entitled “Canadian Society of Biochemistry, Molecular & Cellular Biology 52nd Annual Meeting — Protein Folding: Principles and Diseases” and has undergone the Journal's usual peer review process.","year":2010,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; Ontario Ministry of Health and Long-Term Care","keywords":"Biology; Amino acid; Disease; Prion protein; Genetics; Peptide sequence; Recombinant DNA; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004456458,0.0002110643,0.0002751655,0.0006022783,0.0002560628,0.000575882,0.0002408451,0.0004575819,0.002374355],"category_scores_gemma":[0.001381401,0.000153278,0.000176079,0.0003057568,0.0003626176,0.0004277101,0.0004152287,0.0004777571,0.0003316648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002515734,"about_ca_system_score_gemma":0.00023368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004793349,"about_ca_topic_score_gemma":0.0003776492,"domain_scores_codex":[0.999779,0.0000537825,0.00002256454,0.00004226593,0.00004965949,0.00005269731],"domain_scores_gemma":[0.9986935,0.0002416553,0.0005761043,0.00006349952,0.0001030181,0.0003222033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002353974,0.0004699953,0.2565313,0.0002535995,0.0002186282,0.001301868,0.000957498,0.0004062412,0.7219129,0.002375701,0.0009413502,0.01227699],"study_design_scores_gemma":[0.00003753738,0.0005164996,0.9760275,0.00003966341,0.00007207173,0.003097205,0.0003865026,0.0008600015,0.014101,0.002838001,0.001988669,0.00003533844],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.995815,0.00259297,0.0004135917,0.0001689864,0.00001496563,0.00001421372,0.00007058852,0.00001165741,0.0008980398],"genre_scores_gemma":[0.9989187,0.0005080213,0.0001653039,0.00003262902,0.00001305265,0.000006200275,0.00009111447,0.000007145292,0.0002578883],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.002374355,"threshold_uncertainty_score":0.007942975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02881971860795749,"score_gpt":0.2908248682162812,"score_spread":0.2620051496083237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}