{"id":"W2105956673","doi":"10.1001/jamaoncol.2014.168","title":"Hereditary Diffuse Gastric Cancer Syndrome","year":2015,"lang":"en","type":"article","venue":"JAMA Oncology","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":687,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Dr. H. Bliss Murphy Cancer Centre; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Vancouver General Hospital; Occupational Cancer Research Centre; McGill University Health Centre; University of British Columbia; BC Cancer Agency","funders":"National Institute for Health and Care Research; Cancer Research UK","keywords":"Germline mutation; Medicine; Breast cancer; Cancer; Penetrance; CHEK2; Proband; Genetics; Oncology; Mutation; CDH1; Genetic testing; Internal medicine; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008413496,0.0007612456,0.0002929271,0.0006686004,0.0003752393,0.0001743135,0.0001688917,0.0003449178,0.004933526],"category_scores_gemma":[0.0007058225,0.00009880492,0.0001685328,0.0006822356,0.0003785764,0.0001092468,0.0003538088,0.0002364456,0.0003192626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003340186,"about_ca_system_score_gemma":0.0002309529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002426445,"about_ca_topic_score_gemma":0.003008275,"domain_scores_codex":[0.999887,0.0000119264,0.000007323436,0.00004205697,0.00002556976,0.00002606389],"domain_scores_gemma":[0.9998156,0.00005260935,0.00004883793,0.00001037595,0.00001996887,0.00005246996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004383567,0.000066609,0.5353553,0.0004166566,0.000260443,0.3724506,0.00100425,0.0004607818,0.03466342,0.001926961,0.007071337,0.0458853],"study_design_scores_gemma":[0.0000497853,0.0001321774,0.4147584,0.0000636485,0.00009578054,0.5750273,0.000217221,0.0004130738,0.00228378,0.0004179702,0.006527783,0.00001308433],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901647,0.001576855,0.001088447,0.0003345008,0.00004670221,0.00003597634,0.0008599479,0.0001142617,0.005778521],"genre_scores_gemma":[0.9980944,0.0003584813,0.0003589093,0.00007972175,0.00002091553,0.000006477647,0.0002705995,0.000005479408,0.0008050633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004933526,"threshold_uncertainty_score":0.01650435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02580639391782371,"score_gpt":0.2901571075128544,"score_spread":0.2643507135950307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}