{"id":"W2105956673","doi":"10.1001/jamaoncol.2014.168","title":"Hereditary Diffuse Gastric Cancer Syndrome","year":2015,"lang":"en","type":"article","venue":"JAMA Oncology","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":687,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Dr. H. Bliss Murphy Cancer Centre; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Vancouver General Hospital; Occupational Cancer Research Centre; McGill University Health Centre; University of British Columbia; BC Cancer Agency","funders":"National Institute for Health and Care Research; Cancer Research UK","keywords":"Germline mutation; Medicine; Breast cancer; Cancer; Penetrance; CHEK2; Proband; Genetics; Oncology; Mutation; CDH1; Genetic testing; Internal medicine; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002358222,0.0001552971,0.0001955289,0.00005190311,0.00004601233,0.00001765105,0.0002557706,0.0003043271,0.0001936431],"category_scores_gemma":[0.00008122986,0.0001429962,0.00006210255,0.0001284691,0.00009111117,0.000005982108,0.0001518308,0.0001415505,0.00008647221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001287705,"about_ca_system_score_gemma":0.0006145608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008479036,"about_ca_topic_score_gemma":0.00007428618,"domain_scores_codex":[0.9989148,0.00007890676,0.0002020405,0.0003268199,0.0001521467,0.0003253129],"domain_scores_gemma":[0.9993606,0.00001530543,0.00008470319,0.0002200475,0.0001354169,0.0001839552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005023176,0.0003393421,0.0232975,0.00002411723,0.0002585885,0.0004026412,0.0002693893,0.0002454922,0.08362861,0.00005687392,0.8617737,0.02920145],"study_design_scores_gemma":[0.002624668,0.0010177,0.008733695,0.00001711636,0.00004099631,0.0005722325,0.0001835445,0.00003701856,0.01716218,0.0002264454,0.9690326,0.0003518375],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850428,0.003019709,0.0002168471,0.001653329,0.001435931,0.0001351643,0.00001736333,0.00003081385,0.008448091],"genre_scores_gemma":[0.9892688,0.0003114924,0.001004503,0.002007184,0.0009803525,0.0001297674,0.0001136223,0.0000300594,0.006154225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1072589,"threshold_uncertainty_score":0.5831214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02580639391782371,"score_gpt":0.2901571075128544,"score_spread":0.2643507135950307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}