{"id":"W2106048944","doi":"10.2174/156652311796150408","title":"Polycation-Based Gene Therapy: Current Knowledge and New Perspectives","year":2011,"lang":"en","type":"review","venue":"Current Gene Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital du Sacré-Cœur de Montréal","funders":"Canadian Institutes of Health Research; Universidade Estadual Paulista","keywords":"Genetic enhancement; Gene delivery; Transfection; Viral vector; Vectors in gene therapy; Endosome; Gene; Computational biology; Biology; DNA; Cell biology; Intracellular; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006594157,0.0007376517,0.001101233,0.001210209,0.0002357093,0.001115339,0.000820776,0.001158472,0.002597824],"category_scores_gemma":[0.0003511263,0.00031959,0.000331964,0.001507818,0.0007942633,0.001736544,0.000570692,0.001579485,0.001788021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005422274,"about_ca_system_score_gemma":0.000775789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005508395,"about_ca_topic_score_gemma":0.0008482344,"domain_scores_codex":[0.9998364,0.00002325872,0.0000207742,0.00003112034,0.00006831757,0.00002007143],"domain_scores_gemma":[0.9997533,0.0001201928,0.00003161867,0.00001006015,0.00005646456,0.00002839969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001114384,0.0001580581,0.0001971333,0.01504448,0.00006190878,0.000432537,0.0001243565,0.0007336924,0.01286444,0.007627084,0.01201014,0.9506347],"study_design_scores_gemma":[0.00002674442,0.0002088926,0.0006384589,0.002035402,0.00008324481,0.001890701,0.000108194,0.0003216174,0.004149459,0.00509449,0.9854092,0.00003356639],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003455277,0.9975954,0.0004988918,0.0002948007,0.0001528108,0.000003921426,0.00000961331,0.000008882739,0.001090141],"genre_scores_gemma":[0.001226718,0.9977075,0.0003760046,0.0001193878,0.0001338453,0.000006285177,0.00001473569,0.000001454234,0.0004140381],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002597824,"threshold_uncertainty_score":0.008690655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1299415751517722,"score_gpt":0.3775373899093568,"score_spread":0.2475958147575846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}