{"id":"W2106048944","doi":"10.2174/156652311796150408","title":"Polycation-Based Gene Therapy: Current Knowledge and New Perspectives","year":2011,"lang":"en","type":"review","venue":"Current Gene Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital du Sacré-Cœur de Montréal","funders":"Canadian Institutes of Health Research; Universidade Estadual Paulista","keywords":"Genetic enhancement; Gene delivery; Transfection; Viral vector; Vectors in gene therapy; Endosome; Gene; Computational biology; Biology; DNA; Cell biology; Intracellular; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001667918,0.0007478955,0.0008831067,0.0001967415,0.0001220503,0.00006244025,0.0005839078,0.0003184395,0.0001265416],"category_scores_gemma":[0.00001507403,0.0005972142,0.0005779145,0.0001813927,0.0001375296,0.000007160137,0.0001031573,0.0003206901,0.00009384697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004825994,"about_ca_system_score_gemma":0.001051995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001644015,"about_ca_topic_score_gemma":0.000005502678,"domain_scores_codex":[0.9977227,0.0002226782,0.0004989932,0.001008189,0.0001305887,0.000416878],"domain_scores_gemma":[0.9984061,0.00002354972,0.000325375,0.0008281909,0.0001776717,0.000239176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006975594,0.0003190477,0.00001864644,0.0003579862,0.0002311234,4.029517e-7,0.0002393963,2.269711e-7,0.001254171,0.00002174618,0.004761922,0.9927256],"study_design_scores_gemma":[0.0007314063,0.0004430795,0.00002674152,0.0008055528,0.0001019852,0.000009717121,0.00001478745,0.000002718574,0.005656471,0.00003315464,0.9914922,0.0006821625],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002587301,0.9944939,0.0006192427,0.0000135743,0.001260623,0.0008095856,0.0000878059,0.0000325922,0.00009538458],"genre_scores_gemma":[0.0003155048,0.9963419,0.0001059072,0.00003113778,0.001821275,0.0001608257,0.000802762,0.0001003835,0.0003203225],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9920434,"threshold_uncertainty_score":0.9996479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1299415751517722,"score_gpt":0.3775373899093568,"score_spread":0.2475958147575846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}