{"id":"W2106091291","doi":"10.1093/carcin/bgt320","title":"miR-200b suppresses invasiveness and modulates the cytoskeletal and adhesive machinery in esophageal squamous cell carcinoma cells via targeting Kindlin-2","year":2013,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"General Hospital of People’s Liberation Army; Chinese Academy of Medical Sciences; Chinese Academy of Sciences; Academy of Medical Sciences","keywords":"Gene knockdown; Downregulation and upregulation; Cancer research; Transfection; Focal adhesion; Biology; microRNA; Actin cytoskeleton; Cell growth; Cell biology; Cytoskeleton; Cell migration; Metastasis; Cell; Cell culture; Signal transduction; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001275225,0.0002581252,0.0002038964,0.00006812729,0.0001333397,0.00005933882,0.0001769485,0.0001678501,0.00002444495],"category_scores_gemma":[0.00004487471,0.0002128097,0.00007198063,0.00009637217,0.0001570235,0.00001581356,0.0002203841,0.00008388032,0.000007027713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001977719,"about_ca_system_score_gemma":0.00004980593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004423201,"about_ca_topic_score_gemma":0.00004654282,"domain_scores_codex":[0.9986431,0.0001617914,0.0002588882,0.0004906109,0.0001182134,0.0003273686],"domain_scores_gemma":[0.9992921,0.00007253951,0.0001031437,0.0003151147,0.00009498081,0.0001221469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002416974,0.00006755944,0.09692775,0.0001212756,0.00001034552,0.00001172462,0.0001172514,0.0001541679,0.9018599,0.000002360314,0.0002417178,0.0004617549],"study_design_scores_gemma":[0.0007364598,0.00004538617,0.2832817,0.00000494229,0.00003158877,0.00001428531,0.0001023789,0.0007220128,0.7147542,0.00004210753,0.00007094848,0.0001939778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874562,0.01172115,0.00008585931,0.00008079263,0.00007856401,0.0004915846,0.00003357833,0.00000959461,0.0000427059],"genre_scores_gemma":[0.9991668,0.00008578149,0.0001904827,0.0001147571,0.0001549168,0.00007824416,0.0001064073,0.00004112154,0.00006141872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1871057,"threshold_uncertainty_score":0.8678129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00502848972439076,"score_gpt":0.1946386677511515,"score_spread":0.1896101780267608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}