{"id":"W2106091291","doi":"10.1093/carcin/bgt320","title":"miR-200b suppresses invasiveness and modulates the cytoskeletal and adhesive machinery in esophageal squamous cell carcinoma cells via targeting Kindlin-2","year":2013,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"General Hospital of People’s Liberation Army; Chinese Academy of Medical Sciences; Chinese Academy of Sciences; Academy of Medical Sciences","keywords":"Gene knockdown; Downregulation and upregulation; Cancer research; Transfection; Focal adhesion; Biology; microRNA; Actin cytoskeleton; Cell growth; Cell biology; Cytoskeleton; Cell migration; Metastasis; Cell; Cell culture; Signal transduction; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000120578,0.0002842249,0.0003461901,0.0002304111,0.0001441824,0.0002727097,0.0001328429,0.0001964037,0.0006530657],"category_scores_gemma":[0.0001217327,0.0001588637,0.0001999688,0.0001464497,0.0001541682,0.0001048352,0.0001376221,0.0003791284,0.0002970652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000196616,"about_ca_system_score_gemma":0.0001789899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003926812,"about_ca_topic_score_gemma":0.0007729576,"domain_scores_codex":[0.9998914,0.00002057456,0.00001497828,0.00001661144,0.00003491932,0.00002144369],"domain_scores_gemma":[0.9999527,0.000007938248,0.00001392086,0.000006692941,0.000006525348,0.00001217029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000130129,0.00003395466,0.0002846065,0.0000405356,0.000008330602,0.0000595407,0.0000164815,0.00005820567,0.9977776,0.00005402843,0.00008164198,0.001454904],"study_design_scores_gemma":[0.00005582908,0.0005044917,0.01203139,0.000009057277,0.00004636571,0.0005956696,0.00005715952,0.002881474,0.9797387,0.0000788569,0.00399281,0.000008191523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951267,0.001764609,0.001174703,0.0001017086,0.00002620823,0.00002821726,0.0002646311,0.0001256696,0.00138753],"genre_scores_gemma":[0.9962698,0.0007972297,0.001226676,0.00007724971,0.000005818173,0.00004310552,0.0004096797,0.00001728686,0.00115311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006530657,"threshold_uncertainty_score":0.002184689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00502848972439076,"score_gpt":0.1946386677511515,"score_spread":0.1896101780267608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}