{"id":"W2106100778","doi":"10.1261/rna.2161303","title":"RNA aptamers to initiation factor 4A helicase hinder cap-dependent translation by blocking ATP hydrolysis","year":2003,"lang":"en","type":"article","venue":"RNA","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Mitsubishi Foundation; Ministry of Education, Culture, Sports, Science and Technology; Bio-oriented Technology Research Advancement Institution; Japan Health Sciences Foundation","keywords":"eIF4A; Biology; RNA; Helicase; RNA Helicase A; Eukaryotic initiation factor; Eukaryotic translation; ATP hydrolysis; Internal ribosome entry site; EIF4G; Conformational change; Biochemistry; Cell biology; Ribosome; Translation (biology); Initiation factor; Binding site; Messenger RNA; ATPase; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001899701,0.0004596294,0.0002678753,0.0001872962,0.0001104951,0.0002349597,0.0002565848,0.0004503666,0.001065818],"category_scores_gemma":[0.000274924,0.0002358827,0.0002345577,0.00007577393,0.0002042925,0.0001363766,0.000162339,0.0004476731,0.0004002255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002136367,"about_ca_system_score_gemma":0.0001039434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001145314,"about_ca_topic_score_gemma":0.0001947169,"domain_scores_codex":[0.9997445,0.00004779063,0.00001615006,0.00006022353,0.00006799482,0.00006322143],"domain_scores_gemma":[0.9997901,0.00007660597,0.00006346615,0.0000159465,0.00001968298,0.00003413954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004363199,0.00002665001,0.00004076563,0.00002147397,0.000004236249,0.00001864812,0.000007434516,0.0001765853,0.9983113,0.00007583655,0.00002808756,0.001245284],"study_design_scores_gemma":[0.00001962722,0.0003822689,0.0003473488,0.000002710844,0.00001025993,0.00008653727,0.000005095758,0.001600979,0.9963431,0.00003130337,0.001166683,0.000004213327],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814436,0.001886797,0.01322944,0.0001176728,0.00007889624,0.0001024233,0.000081976,0.0002780087,0.002781316],"genre_scores_gemma":[0.9902264,0.0005357208,0.006342079,0.000151246,0.00002956144,0.00009762893,0.0001595036,0.00003762308,0.00242027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001065818,"threshold_uncertainty_score":0.00356555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01885505316455592,"score_gpt":0.2482975357730256,"score_spread":0.2294424826084697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}