{"id":"W2106100778","doi":"10.1261/rna.2161303","title":"RNA aptamers to initiation factor 4A helicase hinder cap-dependent translation by blocking ATP hydrolysis","year":2003,"lang":"en","type":"article","venue":"RNA","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Mitsubishi Foundation; Ministry of Education, Culture, Sports, Science and Technology; Bio-oriented Technology Research Advancement Institution; Japan Health Sciences Foundation","keywords":"eIF4A; Biology; RNA; Helicase; RNA Helicase A; Eukaryotic initiation factor; Eukaryotic translation; ATP hydrolysis; Internal ribosome entry site; EIF4G; Conformational change; Biochemistry; Cell biology; Ribosome; Translation (biology); Initiation factor; Binding site; Messenger RNA; ATPase; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001557073,0.000157288,0.0001283605,0.00004922895,0.00009297569,0.00003338868,0.0001021493,0.0001609368,0.0001653885],"category_scores_gemma":[0.00006138378,0.0001592754,0.00009115195,0.00008358601,0.00001104404,0.000007091,0.0000138883,0.00006046179,0.00004193977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002214719,"about_ca_system_score_gemma":0.00003246945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002987223,"about_ca_topic_score_gemma":0.00001660551,"domain_scores_codex":[0.9989528,0.00009916061,0.0001968833,0.0003304166,0.0001929151,0.0002278042],"domain_scores_gemma":[0.9995077,0.00001122485,0.0000737368,0.0002486581,0.00004001976,0.0001187152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002707829,0.00002934363,0.00002562861,0.000006347749,0.00003730302,0.000002294495,0.000184971,0.00006522064,0.9757137,0.00001951579,0.0001873645,0.02370129],"study_design_scores_gemma":[0.0002481016,0.00009592085,0.00003153183,0.000008834792,0.0000240807,0.000005453997,0.00006401737,0.00004703089,0.9787847,0.00005491264,0.02042983,0.000205608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9661536,0.0006519941,0.03075583,0.0003098199,0.0001484582,0.0002979179,0.00004191623,0.00002136172,0.001619129],"genre_scores_gemma":[0.9978399,0.00008593381,0.001028228,0.0004698557,0.00008328449,0.00003881062,0.00006050155,0.00002865771,0.0003648173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03168634,"threshold_uncertainty_score":0.6495062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01885505316455592,"score_gpt":0.2482975357730256,"score_spread":0.2294424826084697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}