{"id":"W2106104034","doi":"10.1128/mcb.20.12.4474-4481.2000","title":"Disruption of the Murine Calpain Small Subunit Gene, <i>Capn4</i> : Calpain Is Essential for Embryonic Development but Not for Cell Growth and Division","year":2000,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":329,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Cancer Institute; Medical Research Council; Medical Research Council Canada; Agence Nationale pour la Gestion des Déchets Radioactifs","keywords":"Calpain; Biology; Cell biology; Proteases; Embryonic stem cell; Cell division; Calpastatin; Organogenesis; Protein subunit; Molecular biology; Gene; Cell; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002900122,0.0001901641,0.0001840913,0.00003916074,0.0001843659,0.00001431363,0.0001080931,0.0002502855,0.00001697539],"category_scores_gemma":[0.00003195234,0.0001479069,0.0001397788,0.00005955563,0.0001464203,0.000002825458,0.00008374436,0.0000600567,6.932544e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008053803,"about_ca_system_score_gemma":0.0000592026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002537369,"about_ca_topic_score_gemma":0.00001558107,"domain_scores_codex":[0.9988766,0.0001274833,0.0002625374,0.0004256776,0.00006752248,0.0002401774],"domain_scores_gemma":[0.9995086,0.00002459806,0.000097073,0.0002217315,0.00007446561,0.00007350104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002408044,0.00005768848,0.0006446269,0.0001120789,0.00004121275,4.968435e-7,0.00004857134,0.00001555014,0.9903715,0.0001601631,0.00006048208,0.008246794],"study_design_scores_gemma":[0.00132544,0.0003016649,0.0008610606,0.00001054593,0.00004725766,0.000006155368,0.00002073073,0.0005132193,0.9786031,0.0001981431,0.01791825,0.000194465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.866791,0.001092611,0.1309767,0.000272464,0.0000868987,0.0006755385,0.00005936797,0.000007151774,0.00003833814],"genre_scores_gemma":[0.9960505,0.0001292625,0.001582353,0.0004708756,0.00007615334,0.0001001137,0.0004783433,0.00002448888,0.001087938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1293943,"threshold_uncertainty_score":0.6031467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005371950729403201,"score_gpt":0.202086644483863,"score_spread":0.1967146937544599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}