{"id":"W2106104034","doi":"10.1128/mcb.20.12.4474-4481.2000","title":"Disruption of the Murine Calpain Small Subunit Gene, <i>Capn4</i> : Calpain Is Essential for Embryonic Development but Not for Cell Growth and Division","year":2000,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":329,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Cancer Institute; Medical Research Council; Medical Research Council Canada; Agence Nationale pour la Gestion des Déchets Radioactifs","keywords":"Calpain; Biology; Cell biology; Proteases; Embryonic stem cell; Cell division; Calpastatin; Organogenesis; Protein subunit; Molecular biology; Gene; Cell; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001550724,0.0008092583,0.0002531544,0.0006094711,0.0002678769,0.0003240615,0.0005790565,0.0005444171,0.001679718],"category_scores_gemma":[0.0002398094,0.0003413256,0.0003225976,0.0002364727,0.0005659876,0.0002267448,0.0003488062,0.0005490782,0.0006932407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006304357,"about_ca_system_score_gemma":0.0002906013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001033113,"about_ca_topic_score_gemma":0.00166028,"domain_scores_codex":[0.9997844,0.00002949084,0.00003079063,0.00005654968,0.00005784387,0.00004099977],"domain_scores_gemma":[0.9996741,0.00005134507,0.0001404889,0.00003047316,0.00002158434,0.00008206923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001146963,0.0000241925,0.0001753541,0.00003368086,0.000006345851,0.0001517003,0.000009221472,0.0000772707,0.9982271,0.0001701291,0.00009481029,0.0009155608],"study_design_scores_gemma":[0.00004818821,0.0002209964,0.004727803,0.00001485058,0.00003256919,0.001075686,0.00002379591,0.001206337,0.9865587,0.00009754423,0.005984718,0.000008782054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844543,0.001329836,0.008263544,0.0002169691,0.000100681,0.0001071702,0.002247682,0.0003837708,0.002896043],"genre_scores_gemma":[0.9770219,0.0009286898,0.008428304,0.0001236456,0.00003856661,0.0001218468,0.003152116,0.0002038105,0.009981225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001679718,"threshold_uncertainty_score":0.005619228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005371950729403201,"score_gpt":0.202086644483863,"score_spread":0.1967146937544599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}