{"id":"W2106109508","doi":"10.1021/tx025641h","title":"Nitrosation, Nitration, and Autoxidation of the Selective Estrogen Receptor Modulator Raloxifene by Nitric Oxide, Peroxynitrite, and Reactive Nitrogen/Oxygen Species","year":2003,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Cancer Institute","keywords":"Chemistry; Peroxynitrite; Raloxifene; Autoxidation; Selective estrogen receptor modulator; Furoxan; Nitration; Nitrosation; Nitric oxide; Medicinal chemistry; Organic chemistry; Estrogen receptor; Superoxide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007822293,0.000174088,0.0002276477,0.0001341151,0.0001360813,0.00002397751,0.0001725894,0.0004504883,0.00001024031],"category_scores_gemma":[0.001805148,0.0001426659,0.00005322425,0.0005603435,0.0006354488,0.00001703134,0.0001367669,0.0004957756,0.000002204934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009417672,"about_ca_system_score_gemma":0.0002441254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002652158,"about_ca_topic_score_gemma":0.000004203594,"domain_scores_codex":[0.9979047,0.0006399621,0.0003071601,0.0004647624,0.0002659693,0.0004174632],"domain_scores_gemma":[0.9989633,0.0002261002,0.0001030657,0.0002477322,0.000319145,0.0001406462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001566352,0.000133611,0.01815308,0.00002296032,0.00005690408,8.783676e-7,0.00004551261,0.000002829394,0.9787787,0.001033781,0.001353647,0.0002614844],"study_design_scores_gemma":[0.0008666348,0.0002043316,0.005457095,0.00001493132,0.00001220099,0.00002626064,0.0001146899,0.00003840001,0.9894571,0.00215421,0.001518387,0.0001357289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99631,0.002182521,0.00002875187,0.0002937604,0.00002712795,0.0005734947,0.00002454861,0.000007333543,0.000552453],"genre_scores_gemma":[0.9985923,0.0005158437,0.0004095654,0.00005457528,0.00004331407,0.00008914786,0.00008598802,0.00002148653,0.0001878177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01269598,"threshold_uncertainty_score":0.5817745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0170087799533796,"score_gpt":0.2859604603022867,"score_spread":0.268951680348907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}