{"id":"W2106109508","doi":"10.1021/tx025641h","title":"Nitrosation, Nitration, and Autoxidation of the Selective Estrogen Receptor Modulator Raloxifene by Nitric Oxide, Peroxynitrite, and Reactive Nitrogen/Oxygen Species","year":2003,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Cancer Institute","keywords":"Chemistry; Peroxynitrite; Raloxifene; Autoxidation; Selective estrogen receptor modulator; Furoxan; Nitration; Nitrosation; Nitric oxide; Medicinal chemistry; Organic chemistry; Estrogen receptor; Superoxide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001796566,0.0003375552,0.000192873,0.0001107214,0.0001268391,0.000110276,0.0001711213,0.0002157257,0.0009575813],"category_scores_gemma":[0.0001718872,0.00009457844,0.0002129651,0.00006170354,0.0001541495,0.0001324806,0.0002111829,0.0002043749,0.0001857694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001271779,"about_ca_system_score_gemma":0.0001707881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004703438,"about_ca_topic_score_gemma":0.0008600357,"domain_scores_codex":[0.999886,0.0000278148,0.000005730655,0.00002438204,0.00003385931,0.00002217139],"domain_scores_gemma":[0.99992,0.000009090313,0.00003281286,0.00001090696,0.00001599135,0.00001122127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002193801,0.00002583132,0.001017604,0.00009454401,0.00002130957,0.00006063722,0.00002586346,0.0001081402,0.9925663,0.0001979188,0.00006661067,0.005595752],"study_design_scores_gemma":[0.0000175953,0.0004727535,0.004975646,0.000005971856,0.0000193373,0.0002963688,0.0000288655,0.0008195149,0.989877,0.0001452984,0.003337563,0.000004015889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812682,0.007423707,0.008368243,0.0000817682,0.00004154051,0.00006366566,0.0001116372,0.00005056007,0.002590686],"genre_scores_gemma":[0.9890305,0.002874069,0.003632071,0.00007628551,0.00001515281,0.00006132835,0.0002344803,0.00001423577,0.004061654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009575813,"threshold_uncertainty_score":0.003203392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0170087799533796,"score_gpt":0.2859604603022867,"score_spread":0.268951680348907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}