{"id":"W2106141944","doi":"10.1158/0008-5472.can-05-1061","title":"Identification of Small Molecules that Sensitize Resistant Tumor Cells to Tumor Necrosis Factor-Family Death Receptors","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Global Health Research; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"","keywords":"Tumor necrosis factor alpha; Apoptosis; Programmed cell death; Receptor; Fas ligand; Cell biology; Caspase; Biology; Necroptosis; Fas receptor; Cancer research; Chemistry; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001557682,0.0007115805,0.0008208855,0.0007209802,0.0001574987,0.0004338258,0.0003825768,0.0003238836,0.002222589],"category_scores_gemma":[0.0002371034,0.0002909237,0.0004234185,0.0004438417,0.0002097446,0.0002741429,0.0002524193,0.0006190243,0.0007072368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003549552,"about_ca_system_score_gemma":0.000334763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004008036,"about_ca_topic_score_gemma":0.00120518,"domain_scores_codex":[0.999872,0.00001834854,0.00001237409,0.0000294666,0.0000318148,0.00003595657],"domain_scores_gemma":[0.9998679,0.00003061762,0.00003164018,0.00001681436,0.00002330328,0.00002963501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002502565,0.0003264869,0.0005345616,0.0001626121,0.00003520999,0.0002051694,0.00003863743,0.001294823,0.9821353,0.0002580888,0.0001641982,0.01459476],"study_design_scores_gemma":[0.0004879016,0.006802796,0.005148488,0.00004574282,0.0001807468,0.001048003,0.00006094801,0.001913845,0.9747773,0.0001861253,0.009308506,0.00003957273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829558,0.00447479,0.005843559,0.0001863963,0.00003708947,0.0005919628,0.001146766,0.0002313688,0.004532192],"genre_scores_gemma":[0.9745888,0.006062882,0.01040644,0.0002420961,0.00002938144,0.0003610787,0.002856669,0.000047384,0.005405306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002222589,"threshold_uncertainty_score":0.007435322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04177600888919953,"score_gpt":0.3143796648450956,"score_spread":0.2726036559558961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}