{"id":"W2106161388","doi":"10.1021/ja4001823","title":"Investigation of Fungal Iterative Polyketide Synthase Functions Using Partially Assembled Intermediates","year":2013,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Center for Chronic Disease Prevention and Health Promotion; National Institutes of Health; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Polyketide; Chemistry; Polyketide synthase; Acyl carrier protein; Enzyme; Biochemistry; Biosynthesis; Domain (mathematical analysis); Stereochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001629791,0.0003387157,0.0001181058,0.0001200391,0.00009354435,0.0002244495,0.0001978928,0.0001826498,0.0002416409],"category_scores_gemma":[0.0001530404,0.00009471743,0.0001717357,0.0001357885,0.000146716,0.0002503652,0.0001401809,0.000310371,0.0001569351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002370528,"about_ca_system_score_gemma":0.00015455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004316965,"about_ca_topic_score_gemma":0.0003694456,"domain_scores_codex":[0.9999299,0.00001810994,0.000006708458,0.00001283124,0.0000188424,0.00001366195],"domain_scores_gemma":[0.9999086,0.00002395008,0.00001782996,0.00001417873,0.00001571323,0.00001968953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000820582,0.00002430818,0.0002951767,0.000018931,0.00000282696,0.00005044844,0.00001621128,0.0001844662,0.9981566,0.0001616214,0.000005271602,0.001001965],"study_design_scores_gemma":[0.000005625544,0.0002202266,0.00122337,0.000002151983,0.000007682977,0.0001274427,0.00001911574,0.001005469,0.9967278,0.00005149602,0.000606232,0.000003318992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964863,0.0003505287,0.002296752,0.00001555661,0.00000271246,0.00001528582,0.000101742,0.00001967889,0.0007114831],"genre_scores_gemma":[0.9943244,0.000448366,0.004293443,0.000008075411,0.00000227209,0.000008863507,0.0003660485,0.000006659162,0.0005417621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004316965,"threshold_uncertainty_score":0.001719892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01942869025327548,"score_gpt":0.2590195374721835,"score_spread":0.239590847218908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}