{"id":"W2106189584","doi":"10.1128/jvi.00796-09","title":"Host Cell Detection of Noncoding Stuffer DNA Contained in Helper-Dependent Adenovirus Vectors Leads to Epigenetic Repression of Transgene Expression","year":2009,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Biology; Transgene; Chromatin; DNA methylation; DNA; Epigenetics; Gene delivery; Genetic enhancement; Histone; Gene; Psychological repression; Molecular biology; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000274418,0.0002685712,0.000213212,0.0001225781,0.00009574896,0.000402642,0.0001623327,0.0001965809,0.001219316],"category_scores_gemma":[0.000206792,0.0001577594,0.0001588186,0.00009324351,0.0003560117,0.0001851037,0.0002142484,0.0005718938,0.0003604756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003089245,"about_ca_system_score_gemma":0.0002678618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000419865,"about_ca_topic_score_gemma":0.0008579154,"domain_scores_codex":[0.9997899,0.00002925737,0.00001800003,0.00004964767,0.00006683622,0.00004634562],"domain_scores_gemma":[0.9997266,0.0001288826,0.00004408575,0.00003330605,0.00002112427,0.00004598432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002391893,0.000007469213,0.00008813278,0.00001007106,0.000001177727,0.00001344915,0.00001007139,0.00001019295,0.9994453,0.00009676022,0.000003958367,0.0002895048],"study_design_scores_gemma":[0.000003711636,0.00008354658,0.0008317084,0.000001445221,0.000003486356,0.00004068533,0.00001060798,0.0002464547,0.9983115,0.00001964916,0.0004461298,0.00000107538],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935386,0.0008877317,0.004420441,0.00004012241,0.00002703483,0.00001707072,0.00009061277,0.00005329065,0.0009251629],"genre_scores_gemma":[0.993979,0.0003762659,0.002793108,0.00002079209,0.000007093386,0.00001121925,0.0003004443,0.00002030041,0.002491701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001219316,"threshold_uncertainty_score":0.004078984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01442243367945391,"score_gpt":0.297011611870326,"score_spread":0.2825891781908721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}