{"id":"W2106193331","doi":"10.1021/jm000079i","title":"Novel Radiotracers for Imaging the Serotonin Transporter by Positron Emission Tomography:  Synthesis, Radiosynthesis, and in Vitro and ex Vivo Evaluation of <sup>11</sup>C-Labeled 2-(Phenylthio)araalkylamines","year":2000,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":250,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Serotonin transporter; Chemistry; Ex vivo; Biodistribution; Positron emission tomography; In vivo; Radiosynthesis; Serotonin; Serotonin Plasma Membrane Transport Proteins; Radioligand; Spect imaging; Preclinical imaging; Transporter; Binding potential; In vitro; Biochemistry; Nuclear medicine; Receptor; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001504976,0.0002687986,0.0004777735,0.0001055396,0.00009735339,0.00003597871,0.0003329835,0.0001032908,0.0001704502],"category_scores_gemma":[0.0003204338,0.0001944462,0.0001320965,0.000213947,0.0003551143,0.0002961006,0.000008372233,0.0003711155,1.099266e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007623271,"about_ca_system_score_gemma":0.0001051892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001304314,"about_ca_topic_score_gemma":4.086552e-7,"domain_scores_codex":[0.9974273,0.0001471931,0.0007854662,0.0003570523,0.0009707596,0.0003122675],"domain_scores_gemma":[0.9985077,0.0006012974,0.000394599,0.0001997604,0.0001190419,0.0001776246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006214635,0.0001420981,0.003985219,0.0001585029,0.00001101705,0.00001315774,0.0004831827,0.00004630558,0.9717562,1.38789e-7,0.00008669943,0.02269601],"study_design_scores_gemma":[0.002437872,0.00005663165,0.002442985,0.0004706442,0.0003297351,0.00078637,0.0002439644,0.002461985,0.9902477,0.0000120934,0.0003380262,0.0001720196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963608,0.001514545,0.00006699865,0.001446957,0.00003640617,0.0004825265,0.0000450881,0.000009094184,0.00003752325],"genre_scores_gemma":[0.9988983,0.0003709549,0.00032985,0.0002109345,0.00009149047,0.00003570337,0.000001397234,0.00002897714,0.00003245017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02252399,"threshold_uncertainty_score":0.7929284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01688585796278877,"score_gpt":0.2713882109813364,"score_spread":0.2545023530185476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}