{"id":"W2106211984","doi":"10.1084/jem.20131540","title":"The TCR ligand-inducible expression of CD73 marks γδ lineage commitment and a metastable intermediate in effector specification","year":2014,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Novo Nordisk Fonden","keywords":"Effector; Lineage (genetic); Ligand (biochemistry); T-cell receptor; Expression (computer science); Metastability; Cell biology; Chemistry; Biology; Receptor; Gene; Computer science; Immunology; Genetics; T cell; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009615815,0.0001517746,0.0001365199,0.0003789206,0.0002325646,0.0005302843,0.0001735973,0.0002461089,0.001299796],"category_scores_gemma":[0.0001161253,0.0001234047,0.000115568,0.0002700337,0.0002207509,0.0002731416,0.0002378059,0.0004503323,0.000390557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003250619,"about_ca_system_score_gemma":0.0002509599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000443281,"about_ca_topic_score_gemma":0.00114523,"domain_scores_codex":[0.9998912,0.00001356257,0.000008084798,0.00002543743,0.00002329311,0.00003843858],"domain_scores_gemma":[0.999898,0.00001879093,0.0000247952,0.0000145984,0.00001140441,0.00003242838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005481627,0.00000998667,0.0006883817,0.000008881091,0.000001407694,0.00008467114,0.00001698981,0.00002670622,0.9970613,0.0002660684,0.00001367669,0.00176704],"study_design_scores_gemma":[0.000006272301,0.0001279879,0.01231723,0.000006685635,0.000007510283,0.0005431526,0.00009068289,0.000443461,0.9847791,0.0001404552,0.00153364,0.000003836364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926044,0.0008807272,0.004299329,0.00003237191,0.000007302024,0.00001133282,0.000144659,0.00005518808,0.001964628],"genre_scores_gemma":[0.9946805,0.0004499648,0.003220756,0.00001709544,0.000004565587,0.0000109669,0.000194829,0.00001097496,0.001410375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001299796,"threshold_uncertainty_score":0.004348278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01469021757185184,"score_gpt":0.2698134370373663,"score_spread":0.2551232194655144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}