{"id":"W2106240581","doi":"10.1111/j.1365-2516.2006.01388.x","title":"Defining ‘full‐length’ recombinant factor VIII: a comparative structural analysis","year":2006,"lang":"en","type":"article","venue":"Haemophilia","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Recombinant DNA; Complementary DNA; Immunoglobulin light chain; Glycoprotein; Computational biology; Coagulation; Heavy chain; Homogeneous; Molecular biology; Biology; Antibody; Genetics; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004004772,0.0003273202,0.0002125953,0.0004304822,0.0001671885,0.0004741075,0.000527313,0.0003777948,0.001331264],"category_scores_gemma":[0.00047762,0.0001596619,0.0003940811,0.0004245012,0.0002682679,0.0004691448,0.0002317606,0.00050225,0.0008381367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003925092,"about_ca_system_score_gemma":0.0002062094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004056763,"about_ca_topic_score_gemma":0.0002822791,"domain_scores_codex":[0.9997532,0.00004347281,0.00002839904,0.00005522176,0.00008508819,0.00003464067],"domain_scores_gemma":[0.9997459,0.00005450493,0.00005918837,0.00003829653,0.00005798198,0.00004399688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001832551,0.00003688075,0.0002405604,0.00005256774,0.00001106011,0.00007518005,0.00002807851,0.00007419365,0.9968636,0.0001481634,0.00005343637,0.002233155],"study_design_scores_gemma":[0.00003501961,0.0009261337,0.01592215,0.00002586046,0.00009235348,0.003185387,0.00007397973,0.001346857,0.9604124,0.0002173432,0.01774531,0.00001713301],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979633,0.004493595,0.01205537,0.0001574854,0.00003147597,0.00006291013,0.001511446,0.00006113105,0.00199362],"genre_scores_gemma":[0.934389,0.004319167,0.04315575,0.0001808403,0.00005073231,0.00009179657,0.01512131,0.0001351716,0.002556369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001331264,"threshold_uncertainty_score":0.00445354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03901552134159868,"score_gpt":0.3383652983311779,"score_spread":0.2993497769895792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}