{"id":"W2106246165","doi":"10.1016/j.neurobiolaging.2015.09.013","title":"Replication study of MATR3 in familial and sporadic amyotrophic lateral sclerosis","year":2015,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Research in Immunology and Cancer; Ontario Institute for Cancer Research; Centre hospitalier universitaire de Québec; Université Laval; Université de Montréal; McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; ALS Society of Canada; Muscular Dystrophy Association","keywords":"Amyotrophic lateral sclerosis; Biology; Missense mutation; RNA splicing; TARDBP; Genetics; Exome sequencing; RNA-binding protein; Mutation; Gene; RNA; Medicine; Disease; Mutant; SOD1; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003780125,0.00009724891,0.0003582119,0.0001651325,0.0000168905,0.00000314696,0.0001005406,0.00007149658,0.000008189926],"category_scores_gemma":[0.00008837581,0.00008108255,0.00002500905,0.0002261235,0.0001705498,0.0000540195,0.0001083534,0.0002014668,0.000002599161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003481355,"about_ca_system_score_gemma":0.00004278652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006481778,"about_ca_topic_score_gemma":0.00002973466,"domain_scores_codex":[0.998808,0.0001542544,0.0003626709,0.0003396966,0.0001409249,0.0001944909],"domain_scores_gemma":[0.9992656,0.00004194086,0.0001110539,0.00040243,0.00009469136,0.00008432159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002512791,0.0002743747,0.8799087,0.00004186212,0.00001729067,0.000009983317,0.00101326,0.0000286205,0.1172454,0.00001019969,0.00003356596,0.001165475],"study_design_scores_gemma":[0.002722787,0.00171695,0.993169,0.00007076296,0.00001877002,0.00001624497,0.000158867,0.0001466026,0.001872824,0.00004644979,0.000007880004,0.00005282985],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987364,0.0000689724,0.000001424335,0.0006384,0.00005549535,0.0004103011,0.000002330235,0.00001759697,0.00006904043],"genre_scores_gemma":[0.9996374,0.00006289891,0.0001219363,0.00007928003,0.00003388245,0.00001092575,0.000006803525,0.0000127423,0.00003411187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1153726,"threshold_uncertainty_score":0.3306451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08652940520768007,"score_gpt":0.3227360690392376,"score_spread":0.2362066638315576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}