{"id":"W2106246165","doi":"10.1016/j.neurobiolaging.2015.09.013","title":"Replication study of MATR3 in familial and sporadic amyotrophic lateral sclerosis","year":2015,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Research in Immunology and Cancer; Ontario Institute for Cancer Research; Centre hospitalier universitaire de Québec; Université Laval; Université de Montréal; McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; ALS Society of Canada; Muscular Dystrophy Association","keywords":"Amyotrophic lateral sclerosis; Biology; Missense mutation; RNA splicing; TARDBP; Genetics; Exome sequencing; RNA-binding protein; Mutation; Gene; RNA; Medicine; Disease; Mutant; SOD1; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004394028,0.001005516,0.0007825363,0.0009010792,0.001762714,0.001057894,0.0012123,0.001418208,0.002938756],"category_scores_gemma":[0.009926277,0.0005603544,0.001326395,0.0009662404,0.0006966724,0.0005747407,0.0009308924,0.001063832,0.0009516892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008588667,"about_ca_system_score_gemma":0.0005583995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01075649,"about_ca_topic_score_gemma":0.009340655,"domain_scores_codex":[0.9968684,0.001156285,0.0002904475,0.001081627,0.0003671499,0.0002359827],"domain_scores_gemma":[0.993644,0.001363563,0.001126817,0.002340859,0.001129592,0.0003951696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00640426,0.0002841906,0.9478275,0.00009760977,0.00234453,0.00210476,0.001822051,0.0002871248,0.02895653,0.0004648677,0.00128759,0.00811895],"study_design_scores_gemma":[0.0003226873,0.001069117,0.9881228,0.00003077083,0.0007336226,0.002752379,0.0008740711,0.0005626538,0.002894622,0.0003942292,0.002206778,0.00003642151],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972994,0.000260598,0.0007455239,0.0000820018,0.00004748454,0.00003649989,0.0009742336,0.00002726839,0.0005271362],"genre_scores_gemma":[0.9982232,0.00003840749,0.0003265265,0.00005278593,0.00001596258,0.00004606574,0.0005965362,0.00003507376,0.0006654693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01075649,"threshold_uncertainty_score":0.02323812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08652940520768007,"score_gpt":0.3227360690392376,"score_spread":0.2362066638315576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}