{"id":"W2106250183","doi":"10.1099/vir.0.83331-0","title":"Identification of residues in the receptor-binding domain (RBD) of the spike protein of human coronavirus NL63 that are critical for the RBD–ACE2 receptor interaction","year":2008,"lang":"en","type":"article","venue":"Journal of General Virology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Science Centre for Human and Animal Health; McMaster University; St. Joseph’s Healthcare Hamilton","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Coronavirus; Receptor; Mutagenesis; Mutant; Virology; Plasma protein binding; Coronavirus disease 2019 (COVID-19); Genetics; Cell biology; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001400487,0.0002544097,0.0002531906,0.0001035686,0.0001357228,0.0001831677,0.0001623813,0.0002425418,0.0006666318],"category_scores_gemma":[0.0001879631,0.0001062645,0.0003775899,0.0000908827,0.0001866213,0.0001781481,0.0001597985,0.0003480955,0.0003463041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002660775,"about_ca_system_score_gemma":0.0002100573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007937931,"about_ca_topic_score_gemma":0.0008312541,"domain_scores_codex":[0.9998995,0.00002318168,0.00001445418,0.00001630971,0.00002842097,0.00001817926],"domain_scores_gemma":[0.9999043,0.00002221315,0.00003013156,0.00001043295,0.00001135577,0.00002161782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002055437,0.00003986657,0.001051021,0.00002332918,0.000007852755,0.0001808528,0.00001640348,0.0002758651,0.9969997,0.00007479375,0.00001949804,0.001105292],"study_design_scores_gemma":[0.00007409907,0.0006868613,0.02275422,0.00001110819,0.00003697687,0.001334527,0.00008041599,0.004565171,0.9688483,0.0001046854,0.001489215,0.0000143024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979421,0.0002522453,0.001386567,0.00003347472,0.000007758527,0.00001478948,0.0001005661,0.00001035695,0.0002520671],"genre_scores_gemma":[0.9974278,0.0001665775,0.001760721,0.00003905006,0.000003864991,0.000008659023,0.000317166,0.000005521753,0.000270532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007937931,"threshold_uncertainty_score":0.002230048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1102688423858871,"score_gpt":0.4099033076782505,"score_spread":0.2996344652923634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}